Minicells: Versatile vectors for targeted drug or si/shRNA cancer therapy

Highlights ► Targeted drug or siRNA delivery in cancer remains a serious hurdle. ► Minicells provide a versatile solution for targeted drug or siRNA delivery. ► Minicell-based delivery packages nanoscale levels of drugs or siRNAs. ► In vivo xenografts in mice show dramatic enhancement of therapeutic...

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Bibliographic Details
Published in:Current opinion in biotechnology 2011-12, Vol.22 (6), p.909-916
Main Authors: MacDiarmid, Jennifer A, Brahmbhatt, Himanshu
Format: Article
Language:English
Subjects:
Animals
antibodies
Antibodies - metabolism
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
case studies
Cells - immunology
Cells - metabolism
Drug Delivery Systems
drug resistance
drug therapy
drugs
Humans
immune response
Internal Medicine
intravenous injection
medicine
mice
neoplasm cells
neoplasms
Neoplasms - therapy
RNA, Small Interfering - administration & dosage
RNA, Small Interfering - therapeutic use
small interfering RNA
toxicity
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Summary:Highlights ► Targeted drug or siRNA delivery in cancer remains a serious hurdle. ► Minicells provide a versatile solution for targeted drug or siRNA delivery. ► Minicell-based delivery packages nanoscale levels of drugs or siRNAs. ► In vivo xenografts in mice show dramatic enhancement of therapeutic index. ► Monkey toxicology trials show repeat dosing without toxicity or immunogenicity.
ISSN:0958-1669
1879-0429
DOI:10.1016/j.copbio.2011.04.008