Resveratrol Reduces TNF-α-induced U373MG Human Glioma Cell Invasion through Regulating NF-κB Activation and uPA/uPAR Expression

High invasiveness of glioma cells is one of the reasons that patients with malignant glioma have a poor prognosis. Resveratrol, a plant compound abundant in the peel of grapes, has been suggested as a potential cancer chemopreventive agent. Therefore, we investigated the effect of resveratrol on gli...

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Bibliographic Details
Published in:Anticancer research 2011-12, Vol.31 (12), p.4223-4230
Main Authors: JINHYUN RYU, BO MI KU, GYEONG JAE CHO, WAN SUNG CHOI, KIM, Nayoung, SANG SOO KANG, YEON KYUNG LEE, JOO YEON JEONG, SEOKMIN KANG, CHOI, Jungil, YANG, Yeongae, DONG HOON LEE, GU SEOB ROH, HYUN JOON KIM
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
Cell Line, Tumor
Cell Survival
Collagen - chemistry
Drug Combinations
Gene Expression Regulation, Neoplastic
Glioma - pathology
Humans
Laminin - chemistry
Medical sciences
Neoplasm Invasiveness
Neurology
NF-kappa B - metabolism
Proteoglycans - chemistry
Receptors, Urokinase Plasminogen Activator - metabolism
RNA, Messenger - metabolism
Stilbenes - pharmacology
Tumor Necrosis Factor-alpha - metabolism
Tumors
Tumors of the nervous system. Phacomatoses
Urokinase-Type Plasminogen Activator - metabolism
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Summary:High invasiveness of glioma cells is one of the reasons that patients with malignant glioma have a poor prognosis. Resveratrol, a plant compound abundant in the peel of grapes, has been suggested as a potential cancer chemopreventive agent. Therefore, we investigated the effect of resveratrol on glioma cell invasion. The effect of resveratrol on U373MG human glioma cell invasion was assessed by Matrigel assay and methylthiazoltetrazolium assay. Western blotting and reverse transcription-polymerase chain reaction were performed to elucidate the action mechanism of resveratrol. Resveratrol reduced tumor necrosis factor (TNF)-α-induced U373MG human glioma cell invasion. In addition, resveratrol repressed nuclear factor kappa B (NF-κB) activation and down-regulated mRNA expression of urokinase plasminogen activator (uPA) and its receptor in TNF-α-treated glioma cells. These findings suggest that resveratrol could prevent glioma cell invasion via inhibiting proteolysis of extracellular matrix.
ISSN:0250-7005
1791-7530