Results of ambulatory pH monitoring do not reliably predict response to therapy in patients with eosinophilic oesophagitis

Aliment Pharmacol Ther 2012; 35: #–# Summary Background  The consensus statements for eosinophilic oesophagitis recommend that ambulatory pH monitoring is one means of determining if gastro‐oesophageal reflux is the cause of oesophageal eosinophilia and should guide pharmacological therapy. Aim  To...

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Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2012-01, Vol.35 (2), p.300-307
Main Authors: Francis, D. L., Foxx-Orenstein, A., Arora, A. S., Smyrk, T. C., Jensen, K., Nord, S. L., Alexander, J. A., Romero, Y., Katzka, D. A.
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Anti-Inflammatory Agents - administration & dosage
Anti-Ulcer Agents - administration & dosage
Biological and medical sciences
budesonide
Budesonide - administration & dosage
Clinical trials
Digestive system
Eosinophilia
Eosinophilic Esophagitis - drug therapy
Eosinophilic Esophagitis - physiopathology
Esomeprazole - administration & dosage
Esophagus
Female
Gastric Acidity Determination
Gastroenterology. Liver. Pancreas. Abdomen
Hematologic and hematopoietic diseases
Humans
Hydrogen-Ion Concentration
Leukocytes (eosinophilic)
Male
Medical sciences
Middle Aged
Monitoring, Ambulatory
Omeprazole
Other diseases. Hematologic involvement in other diseases
Other diseases. Semiology
pH effects
Pharmacology. Drug treatments
Predictive Value of Tests
Prospective Studies
Severity of Illness Index
Treatment Outcome
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Summary:Aliment Pharmacol Ther 2012; 35: #–# Summary Background  The consensus statements for eosinophilic oesophagitis recommend that ambulatory pH monitoring is one means of determining if gastro‐oesophageal reflux is the cause of oesophageal eosinophilia and should guide pharmacological therapy. Aim  To evaluate prospectively the accuracy of pH monitoring as a predictor of endoscopic, histological and symptomatic response in patients with oesophageal eosinophilia. Methods  We conducted a prospective trial in which patients with oesophageal eosinophilic infiltration with ≥15 eos/hpf underwent a 24‐h pH study and were placed in one of two treatment arms for 6 weeks based on positive or negative results. Patients with abnormal acid exposure were treated with esomeprazole 40 mg twice daily and others were treated with oral viscous budesonide 1 g twice daily. Response to treatment was assessed by oesophageal histology (
ISSN:0269-2813
1365-2036
DOI:10.1111/j.1365-2036.2011.04922.x