Hepatic Arterial Buffer Response after Pediatric Living Donor Liver Transplantation: Report of a Case

Abstract Background Excessive portal pressure at an early stage after living-donor liver transplantation (LDLT) can damage sinusoidal endothelial cells and hepatocytes through shear stress leading to graft failure, or hepatic arterial complications due to low hepatic artery flow from a hepatic arter...

Full description

Saved in:
Bibliographic Details
Published in:Transplantation proceedings 2011-12, Vol.43 (10), p.4019-4024
Main Authors: Sanada, Y, Mizuta, K, Urahashi, T, Ihara, Y, Wakiya, T, Okada, N, Yamada, N, Egami, S, Hishikawa, S, Ushijima, K, Otomo, S, Sakamoto, K, Yasuda, Y, Kawarasaki, H
Format: Article
Language:English
Subjects:
Biliary Atresia - surgery
Biological and medical sciences
Blood Flow Velocity
Fundamental and applied biological sciences. Psychology
Fundamental immunology
General aspects
Hepatic Artery - diagnostic imaging
Hepatic Artery - physiopathology
Humans
Infant
Liver Circulation
Liver Transplantation - adverse effects
Liver, biliary tract, pancreas, portal circulation, spleen
Living Donors
Male
Medical sciences
Portal Pressure
Portal Vein - physiopathology
Postoperative Complications - diagnosis
Postoperative Complications - etiology
Postoperative Complications - physiopathology
Regional Blood Flow
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Time Factors
Tissue, organ and graft immunology
Tomography, X-Ray Computed
Treatment Outcome
Ultrasonography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background Excessive portal pressure at an early stage after living-donor liver transplantation (LDLT) can damage sinusoidal endothelial cells and hepatocytes through shear stress leading to graft failure, or hepatic arterial complications due to low hepatic artery flow from a hepatic arterial buffer response. We encountered a case in which excessive portal vein flow was observed from an early stage after pediatric LDLT. The hepatic artery flow decreased due to a hepatic arterial buffer response. Case report A 6-month-old boy with biliary atresia showed excessive portal vein flow early after LDLT with a decreasing hepatic artery flow without anastomotic stenosis from postoperative day 3. The PV flow gradually exhibited a decrease at approximately postoperative day 8 and, similtaneously, hepatic artery flow exhibited improvement. Conclusion Because excessive portal pressure after LDLT is reversible, it has been suggested that it may be possible to prevent the progress of hepatic arterial complications if temporary portal pressure modulation can be performed for cases among the high-risk group for hepatic arterial complications.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2011.08.094