True hypoglycaemia secondary to treatment with granulocyte colony stimulating factor (G-CSF) in a diabetic patient with non-small cell lung cancer

Abstract We report the case of a 61-year-old man with non-small lung cancer with poorly controlled type 2 diabetes mellitus who developed clinically significant hypoglycaemia secondary to a first exposure to granulocyte colony stimulating factor (G-CSF) injections. Whilst artefactual hypoglycaemia d...

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2012-01, Vol.75 (1), p.133-135
Main Authors: Coward, Jermaine I.G, Nathavitharana, Ravindhi, Popat, Sanjay
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood glucose
Carcinoma, Non-Small-Cell Lung - blood
Carcinoma, Non-Small-Cell Lung - drug therapy
Diabetes Mellitus, Type 2 - blood
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
G-CSF
Granulocyte Colony-Stimulating Factor - adverse effects
Granulocyte Colony-Stimulating Factor - therapeutic use
Hematologic and hematopoietic diseases
Hematology, Oncology and Palliative Medicine
Humans
Hypoglycaemia
Hypoglycemia - chemically induced
Leukocytosis - chemically induced
Lung Neoplasms - blood
Lung Neoplasms - drug therapy
Male
Medical sciences
Middle Aged
Neutropenia
Non-small cell lung cancer
Other diseases. Hematologic involvement in other diseases
Pneumology
Pulmonary/Respiratory
Tumors
Tumors of the respiratory system and mediastinum
Type II diabetes
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Summary:Abstract We report the case of a 61-year-old man with non-small lung cancer with poorly controlled type 2 diabetes mellitus who developed clinically significant hypoglycaemia secondary to a first exposure to granulocyte colony stimulating factor (G-CSF) injections. Whilst artefactual hypoglycaemia during treatment with G-CSF is well recognised, to our knowledge, this is the first report revealing that it can provoke true hypoglycaemia in the absence of leucocytosis.
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2011.11.001