Multiple depositions of Ag nanoparticles on chemically modified agarose films for surface-enhanced Raman spectroscopy

A facile and cost-effective approach for the preparation of a surface-enhanced Raman spectroscopy (SERS) substrate through constructing silver nanoparticle/3-aminopropyltriethoxysilane/agarose films (Ag NPs/APTES/Agar film) on various solid supports is described. The SERS performance of the substrat...

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Bibliographic Details
Published in:Nanoscale 2012-01, Vol.4 (1), p.137-142
Main Authors: Zhai, Wen-Lei, Li, Da-Wei, Qu, Lu-Lu, Fossey, John S, Long, Yi-Tao
Format: Article
Language:English
Subjects:
4-Aminobenzoic Acid - chemistry
Aniline Compounds - chemistry
Arrays
Deposition
Metal Nanoparticles - chemistry
Nanocomposites
Nanoparticles
Nanostructure
Quantitative analysis
Raman spectroscopy
Rhodamines - chemistry
Sepharose - chemistry
Silver
Silver - chemistry
Spectrum Analysis, Raman
Sulfhydryl Compounds
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Summary:A facile and cost-effective approach for the preparation of a surface-enhanced Raman spectroscopy (SERS) substrate through constructing silver nanoparticle/3-aminopropyltriethoxysilane/agarose films (Ag NPs/APTES/Agar film) on various solid supports is described. The SERS performance of the substrate was systematically investigated, revealing a maximum SERS intensity with four layers of the Ag NP deposition. The enhancement factor of the developed substrate was calculated as 1.5 × 10(7) using rhodamine 6G (R6G) as the probe molecule, and the reproducibility of the SERS signals was established. A high throughput screening platform was designed, manufactured and implemented which utilised the ability to cast agarose to assemble arrays. Quantitative analysis of 4-aminobenzoic acid (4-ABA) and 4-aminothiophenol (4-ATP) was achieved over a ∼0.5 nM-0.1 μM range.
ISSN:2040-3364
2040-3372
DOI:10.1039/c1nr10956a