Aryl hydrocarbon receptor-mediated Cyp1a1 expression is modulated in a CLOCK-dependent circadian manner

Highlights ► Circadian variation in the expression of AhR in the lungs of mice. ► Benzo[α]pyrene-induced Cyp1a1 expression varied according to its dosing time. ► Circadian variation of AhR-mediated signaling was under the control of the circadian Clock gene.

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2011-12, Vol.290 (2), p.203-207
Main Authors: Tanimura, Naomi, Kusunose, Naoki, Matsunaga, Naoya, Koyanagi, Satoru, Ohdo, Shigehiro
Format: Article
Language:English
Subjects:
Animals
Aryl hydrocarbon receptor
Benzo(a)pyrene - administration & dosage
Benzo(a)pyrene - toxicity
Biological and medical sciences
Circadian Rhythm
Clock gene
CLOCK Proteins - genetics
CLOCK Proteins - metabolism
Cyp1a1
Cytochrome P-450 CYP1A1 - drug effects
Cytochrome P-450 CYP1A1 - genetics
DNA
Drug Administration Schedule
Emergency
enzymes
Gene Expression Regulation, Enzymologic - drug effects
genes
Injections, Intraperitoneal
intraperitoneal injection
linkage (genetics)
Lung - metabolism
lungs
Medical sciences
messenger RNA
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
mutants
mutation
Receptors, Aryl Hydrocarbon - genetics
Receptors, Aryl Hydrocarbon - metabolism
RNA, Messenger - metabolism
signal transduction
Time Factors
Toxicology
toxins
transcription (genetics)
transcription factors
Xenobiotics - administration & dosage
Xenobiotics - toxicity
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Description
Summary:Highlights ► Circadian variation in the expression of AhR in the lungs of mice. ► Benzo[α]pyrene-induced Cyp1a1 expression varied according to its dosing time. ► Circadian variation of AhR-mediated signaling was under the control of the circadian Clock gene.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2011.09.007