In vitro susceptibility of Aspergillus spp. to dithiocarbamate organoruthenium compounds

Summary The in vitro antifungal activity of ruthenium dithiocarbamate compounds (1–5) was investigated and assessed for its activity against seven different species of Aspergillus (Aspergillus clavatus, Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger, Aspergillus nomius, Aspergillus tam...

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Bibliographic Details
Published in:Mycoses 2011-09, Vol.54 (5), p.e323-e329
Main Authors: Nogueira, Luciano J., de Resende, Maria A., Oliveira, Sheila R., de Araújo, Maria Helena, Magalhães, Thais F. F., de Oliveira, Milena B., Martins, Cleide V. B., Lopes, Miriam T. P., Araújo e Silva, Ana C., Donnici, Claudio L.
Format: Article
Language:eng ; ger
Subjects:
amphotericin B
Animals
Antifungal activity
Antifungal agents
Antifungal susceptibility
Aspergillus - drug effects
Aspergillus flavus
Aspergillus fumigatus
Aspergillus niger
Aspergillus nomius
Aspergillus tamarii
Aspergillus terreus
bromides
Cell Line
Cell Survival - drug effects
Cricetinae
Cytotoxicity
cytotoxicity testing
dinuclear ruthenium complexes
Drug development
emerging infectious diseases
fluconazole
Fungi
Mammalian cells
Microbial Sensitivity Tests
Microorganisms
Minimum inhibitory concentration
Ruthenium Compounds - chemistry
Ruthenium Compounds - pharmacology
Ruthenium Compounds - toxicity
Thiocarbamates - chemistry
Thiocarbamates - pharmacology
Thiocarbamates - toxicity
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Summary:Summary The in vitro antifungal activity of ruthenium dithiocarbamate compounds (1–5) was investigated and assessed for its activity against seven different species of Aspergillus (Aspergillus clavatus, Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger, Aspergillus nomius, Aspergillus tamarii and Aspergillus terreus). Analysis of in vitro susceptibility was performed using broth microdilution assay following the Clinical and Laboratory Standards Institute guidelines for filamentous fungi. The cytotoxicity was evaluated using 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay. Aspergillus clavatus and A. fumigatus were more susceptible species for complexes 1 and 2. Other complexes showed excellent minimum inhibitory concentration (4–64 μg ml−1) against most microorganisms. Complexes 1 and 2 are respectively 180‐ and 95‐fold more active than the corresponding free ligands against A. clavatus and the complex 5 is 46‐fold more active than free ligand against A. niger. Aspergillus niger was more susceptible to the action of the complexes 1 and 5 (16 μg ml−1). A low cytotoxic activity (IC50 > 10−6 mol l−1) on normal mammalian cells (BHK‐21) to the evaluated complexes was measured. Ruthenium complexes are promising antifungal agents against the development of novel effective drug against different species of Aspergillus; however, for A. nomius and A. terreus, they were not active in the highest concentration tested.
ISSN:0933-7407
1439-0507
DOI:10.1111/j.1439-0507.2010.01914.x