Hydrogen bonds of anti-HIV active aminophenols

Analysis of IR-Fourier spectra from solutions and crystals of antiviral sulfo-containing aminophenols has shown that various types of intramolecular and intermolecular interactions can occur in molecules of these compounds. Three types of intramolecular hydrogen bonds (O–H⋅⋅⋅N, O–H⋅⋅⋅O=S=O, and N–H⋅...

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Bibliographic Details
Published in:Journal of applied spectroscopy 2011-05, Vol.78 (2), p.197-202
Main Authors: Belkov, M. V., Ksendzova, G. A., Skornyakov, I. V., Sorokin, V. L., Tolstorozhev, G. B., Shadyro, O. I.
Format: Article
Language:English
Subjects:
AIDS (Disease)
Analysis
Analytical Chemistry
Antiviral agents
Atomic/Molecular Structure and Spectra
Health aspects
Highly active antiretroviral therapy
HIV (Viruses)
Human immunodeficiency virus
Hydrogen
Hydrogen bonding
Physics
Physics and Astronomy
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Summary:Analysis of IR-Fourier spectra from solutions and crystals of antiviral sulfo-containing aminophenols has shown that various types of intramolecular and intermolecular interactions can occur in molecules of these compounds. Three types of intramolecular hydrogen bonds (O–H⋅⋅⋅N, O–H⋅⋅⋅O=S=O, and N–H⋅⋅⋅O=S=O) are formed in CCl 4 solutions of the sulfo-containing aminophenols. The formation of intermolecular H-bonds involving the NH- and OH-groups and the preservation of the intramolecular O–H⋅⋅⋅O=S=O H-bond are characteristic of the anti-HIV active aminophenol crystals. Spectral attributes are determined in order to distinguish between the anti-HIV active and inactive sulfo-containing aminophenols.
ISSN:0021-9037
1573-8647
DOI:10.1007/s10812-011-9446-5