Chronic cold stress in mice induces a regulatory phenotype in macrophages: Correlation with increased 11β-hydroxysteroid dehydrogenase expression

Highlight ► Chronic stress induced expression of 11β-HSD in macrophage. These cells exhibited a regulatory phenotype and were able to stimulate T cells to produce regulatory cytokines.

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2012-01, Vol.26 (1), p.50-60
Main Authors: Sesti-Costa, R, Ignacchiti, M.D.C, Chedraoui-Silva, S, Marchi, L.F, Mantovani, B
Format: Article
Language:English
Subjects:
11-beta-Hydroxysteroid Dehydrogenases - biosynthesis
11-beta-Hydroxysteroid Dehydrogenases - physiology
11β-HSD
Actins - metabolism
Allergy and Immunology
Animals
Catecholamine
Chagas Disease - pathology
Chronic Disease
Chronic stress
Coculture Techniques
Cold Temperature - adverse effects
Cytokines - biosynthesis
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Glucocorticoid
Growth hormone
Hormones - blood
Macrophage
Macrophages - physiology
Male
Mice
Mice, Inbred BALB C
Neuroimmunomodulation
Phagocytosis
Phagocytosis - physiology
Psychiatry
Real-Time Polymerase Chain Reaction
Spleen - cytology
Spleen - metabolism
Stress, Physiological - physiology
Superoxides - metabolism
T-Lymphocytes, Regulatory - physiology
Trypanosoma cruzi
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Description
Summary:Highlight ► Chronic stress induced expression of 11β-HSD in macrophage. These cells exhibited a regulatory phenotype and were able to stimulate T cells to produce regulatory cytokines.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2011.07.234