Genetics of Schizophrenia: New Findings and Challenges

The work conducted using genome-wide approaches during the past several years has invigorated the field, and represents the dawn of molecular genetics of schizophrenia. The aggregate data increasingly support a combination of rare and common genetic variation in schizophrenia, a major role for polyg...

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Bibliographic Details
Published in:Annual review of genomics and human genetics 2011-01, Vol.12 (1), p.121-144
Main Authors: Gejman, Pablo V, Sanders, Alan R, Kendler, Kenneth S
Format: Article
Language:English
Subjects:
Adoption
CNV
complex disorders
Genetic Pleiotropy
Genome-Wide Association Study
GWAS
Humans
Mental Disorders - genetics
polygenic
Schizophrenia - genetics
SNP
Twin Studies as Topic
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Summary:The work conducted using genome-wide approaches during the past several years has invigorated the field, and represents the dawn of molecular genetics of schizophrenia. The aggregate data increasingly support a combination of rare and common genetic variation in schizophrenia, a major role for polygenic inheritance, and a genetic overlap of schizophrenia and other psychiatric disorders, such as bipolar disorder and autism. The current and upcoming resequencing programs (full exomes to full genomes), in combination with the use of more informative genotyping arrays, will allow a more thorough dissection of the molecular genetics of the disorder. A main challenge for the field is the translation of established genetic associations into a better pathophysiological understanding of schizophrenia.
ISSN:1527-8204
1545-293X
DOI:10.1146/annurev-genom-082410-101459