Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy

A multivalent galactosyl carborane derivative 10 (dendritic glyco-borane, DGB) was synthesized and demonstrated as a potential cell-targeting agent in BNCT with HepG2 cells. DGB 10 improved the delivery of boron to HepG2 cells and neutron irradiation data show DGB 10 with ten-fold improvement at kil...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (4), p.612-614
Main Authors: Lai, Chian-Hui, Lin, Yu-Chuan, Chou, Fong-In, Liang, Chien-Fu, Lin, En-Wei, Chuang, Yung-Jen, Lin, Chun-Cheng
Format: Article
Language:English
Subjects:
Boranes - chemistry
Boron - administration & dosage
Boron - therapeutic use
Boron Neutron Capture Therapy - methods
Dendrimers - chemistry
Drug Delivery Systems - methods
Galactose - chemistry
Hep G2 Cells
Humans
Neoplasms - radiotherapy
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Summary:A multivalent galactosyl carborane derivative 10 (dendritic glyco-borane, DGB) was synthesized and demonstrated as a potential cell-targeting agent in BNCT with HepG2 cells. DGB 10 improved the delivery of boron to HepG2 cells and neutron irradiation data show DGB 10 with ten-fold improvement at killing the HepG2 cells over BSH.
ISSN:1359-7345
1364-548X
DOI:10.1039/c1cc14447b