Left-ventricular shape determines intramyocardial mechanical heterogeneity

Left-ventricular remodeling is considered to be an important mechanism of disease progression leading to mechanical dysfunction of the heart. However, the interaction between the physiological changes in the remodeling process and the associated mechanical dysfunction is still poorly understood. Cli...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology 2011-12, Vol.301 (6), p.H2351-H2361
Main Authors: Choi, Hon Fai, Rademakers, Frank E, Claus, Piet
Format: Article
Language:English
Subjects:
Biomechanical Phenomena
Cardiovascular disease
Compliance
Computer Simulation
Finite Element Analysis
Heart Ventricles - anatomy & histology
Hemodynamics
Humans
Models, Cardiovascular
Myocardial Contraction
Reproducibility of Results
Simulation
Stress, Mechanical
Stroke Volume
Time Factors
Ventricular Dysfunction, Left - pathology
Ventricular Dysfunction, Left - physiopathology
Ventricular Function, Left
Ventricular Remodeling
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Summary:Left-ventricular remodeling is considered to be an important mechanism of disease progression leading to mechanical dysfunction of the heart. However, the interaction between the physiological changes in the remodeling process and the associated mechanical dysfunction is still poorly understood. Clinically, it has been observed that the left ventricle often undergoes large shape changes, but the importance of left-ventricular shape as a contributing factor to alterations in mechanical function has not been clearly determined. Therefore, the interaction between left-ventricular shape and systolic mechanical function was examined in a computational finite-element study. Hereto, finite-element models were constructed with varying shapes, ranging from an elongated ellipsoid to a sphere. A realistic transmural gradient in fiber orientation was considered. The passive myocardium was described by an incompressible hyperelastic material law with transverse isotropic symmetry. Activation was governed by the eikonal-diffusion equation. Contraction was incorporated using a Hill model. For each shape, simulations were performed in which passive filling was followed by isovolumic contraction and ejection. It was found that the intramyocardial distributions of fiber stress, strain, and stroke work density were shape dependent. Ejection performance was reduced with increasing sphericity, which was regionally related to a reduction in the active fiber stress development, fiber shortening, and stroke work in the midwall and subepicardial region at the midheight level in the left-ventricular wall. Based on these results, we conclude that a significant interaction exists between left-ventricular shape and regional myofiber mechanics, but the importance for left-ventricular remodeling requires further investigation.
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.00568.2011