The ameliorating effect of dantrolene on the morphology of urinary bladder in spinal cord injured rats

In animal models of spinal cord injury (SCI), the urinary bladder can undergo significant structural and physiological alterations. Dantrolene has been shown to be neuroprotective by reducing neuronal apoptosis after SCI. Furthermore, in addition to its anti-inflammatory and antioxidant properties,...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2011-12, Vol.207 (12), p.775-779
Main Authors: Torres, Bruno, Serakides, Rogéria, Caldeira, Fátima, Gomes, Mardelene, Melo, Eliane
Format: Article
Language:English
Subjects:
Animals
Cystitis - drug therapy
Dantrolene
Dantrolene - therapeutic use
Disease Models, Animal
Hemorrhage - complications
Hemorrhage - drug therapy
Male
Neuroprotective Agents - therapeutic use
Rat
Rats
Rats, Wistar
Spinal Cord - drug effects
Spinal Cord Injuries - complications
Spinal Cord Injuries - drug therapy
Spinal Cord Injuries - pathology
Spinal cord injury
Urinary Bladder - drug effects
Urinary Bladder - pathology
Urinary bladder injury
Urinary Bladder, Neurogenic - drug therapy
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Summary:In animal models of spinal cord injury (SCI), the urinary bladder can undergo significant structural and physiological alterations. Dantrolene has been shown to be neuroprotective by reducing neuronal apoptosis after SCI. Furthermore, in addition to its anti-inflammatory and antioxidant properties, it appears to have a beneficial action on voiding, once this drug acts on the external urethral sphincter relaxation. In the present study, we investigated the effects of dantrolene on urinary bladder injury that follows experimental SCI. Forty-six male Wistar rats were laminectomized at T13, and a compressive trauma was performed to induce SCI. After euthanasia, the urinary bladder was removed for gross and histological evaluation. Traumatized animals showed urinary retention with severe hemorrhagic cystitis. Injured animals treated with dantrolene had less bladder hemorrhage and inflammatory infiltrate than those treated with placebo ( p < 0.05). Our results demonstrate that dantrolene may protect against urinary bladder lesions that follow SCI. Treating spinal cord-injured patients with this agent may be a promising additional therapeutic strategy to alleviate the accompanying inflammatory process. The results of the current study show that dantrolene has protective effects on spinal cord contusion-induced urinary bladder injury. The impaired integrity of bladder morphology was ameliorated by dantrolene treatment.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2011.10.004