Antioxidant and cardioprotective effects of Ilex brasiliensis: A comparative study with Ilex paraguariensis (yerba mate)

Our objective was to compare the antioxidant properties and cardiovascular effects in ischemia–reperfusion of leaves aqueous extracts of Ilex brasiliensis (B) and Ilex paraguariensis (P). In vitro systems were used to assess the antioxidant properties of the extracts. Isolated rat hearts were treate...

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Bibliographic Details
Published in:Food research international 2009-12, Vol.42 (10), p.1403-1409
Main Authors: Schinella, Guillermo, Fantinelli, Juliana C., Tournier, Horacio, Prieto, José María, Spegazzini, Etile, Debenedetti, Silvia, Mosca, Susana M.
Format: Article
Language:English
Subjects:
antioxidant activity
Antioxidant capacity
Antioxidants
ascorbic acid
Attenuation
Biological and medical sciences
cardioprotective effect
chemical constituents of plants
Damage
diastolic blood pressure
Food industries
Foods
free radical scavengers
Fundamental and applied biological sciences. Psychology
glutathione
GSH
Ilex
Ilex brasiliensis
Ilex paraguariensis
Ischemia
medicinal plants
myocardial ischemia
Phenols
plant extracts
reactive oxygen species
Reperfusion
Scavenging
superoxide anion
systolic blood pressure
TBARS
tea (beverage)
Thiobarbituric acid
thiobarbituric acid-reactive substances
yerba mate
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Summary:Our objective was to compare the antioxidant properties and cardiovascular effects in ischemia–reperfusion of leaves aqueous extracts of Ilex brasiliensis (B) and Ilex paraguariensis (P). In vitro systems were used to assess the antioxidant properties of the extracts. Isolated rat hearts were treated with both extracts before ischemia and myocardial function was assessed. Thiobarbituric acid reactive substances (TBARS) concentration and reduced glutathione (GSH) were also measured. B extract showed higher total phenols and ascorbic acid contents and a higher scavenging activity of peroxynitrite and ferric reducing antioxidant power (FRAP) than P extract. Postischemic systolic and diastolic functions were improved after B and P treatment. Both extracts decreased TBARS and preserved GSH content. The present study demonstrates that an aqueous extract of I. brasiliensis, similar to I. paraguariensis, protects the myocardium against ischemia–reperfusion injury and attenuates oxidative damage. These effects may be attributed to the potent antioxidant properties of the extract.
ISSN:0963-9969
1873-7145
DOI:10.1016/j.foodres.2009.07.004