Maternal exercise decreases maternal deprivation induced anxiety of pups and correlates to increased prefrontal cortex BDNF and VEGF

► Maternal regular aerobic exercise. ► Increased prefrontal cortex VEGF and BDNF in pups. ► Affected maternal deprivation induced anxiety. ► Decreased anxiety. Maternal deprivation (MD) may cause neuropsychiatric disorders such as anxiety disorder by negatively affecting the cognitive functions and...

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Bibliographic Details
Published in:Neuroscience letters 2011-11, Vol.505 (3), p.273-278
Main Authors: Uysal, Nazan, Sisman, Ali Riza, Dayi, Ayfer, Aksu, Ilkay, Cetin, Ferihan, Gencoglu, Celal, Tas, Aysegul, Buyuk, Erkan
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Anxiety
Anxiety - etiology
Anxiety - metabolism
Anxiety - pathology
BDNF
Biological and medical sciences
Brain-Derived Neurotrophic Factor - metabolism
Corticosterone - blood
Disease Models, Animal
Exploratory Behavior
Female
Fundamental and applied biological sciences. Psychology
Male
Maternal Deprivation
Maternal exercise
Mothers - psychology
Motor Activity - physiology
Physical Conditioning, Animal
Prefrontal cortex
Prefrontal Cortex - metabolism
Pregnancy
Pups
Radioimmunoassay - methods
Rats
Vascular Endothelial Growth Factor A - metabolism
VEGF
Vertebrates: nervous system and sense organs
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Summary:► Maternal regular aerobic exercise. ► Increased prefrontal cortex VEGF and BDNF in pups. ► Affected maternal deprivation induced anxiety. ► Decreased anxiety. Maternal deprivation (MD) may cause neuropsychiatric disorders such as anxiety disorder by negatively affecting the cognitive functions and behavior in pups. The aim of this study is to investigate whether maternal exercise during pregnancy has beneficial effects on anxiety that increases with MD, and on the levels of VEGF and BDNF which have anxiolytic effects on the prefrontal cortex, the anxiety-related region of the brain. The anxiety level in the deprivation group was greater than the control group and found more in male than female pups. The prefrontal cortex VEGF and BDNF levels were decreased in the deprivation group compared to control group while serum corticosterone levels were increased in the deprivation group. Anxiety and serum corticosterone levels were decreased in maternally exercised female and male pups, while the prefrontal cortex VEGF and BDNF levels were increased, compared to sedentary mother's pups. These results indicate that maternal exercise may attenuate the negative effect of stresses such as maternal deprivation that can be encountered early in life.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2011.10.039