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Inhibition of VEGF expression by RNA inference (RNAi) technique as a possible new strategy for prevention of human hypertrophic scar
Hypertrophic scarring remains a major problem for patients who have suffered from surgeries or burns. Since the underlying mechanism of hypertrophic scarring is largely unknown, there is no routinely effective treatment for this disease. Vascularization plays an important role in the early phase of...
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| Published in: | Bioscience hypotheses 2008-01, Vol.1 (5), p.272-274 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
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| Summary: | Hypertrophic scarring remains a major problem for patients who have suffered from surgeries or burns. Since the underlying mechanism of hypertrophic scarring is largely unknown, there is no routinely effective treatment for this disease. Vascularization plays an important role in the early phase of hypertrophic scarring. Therefore, the inhibition of angiogenesis may be used as a preventive strategy. Vascular endothelial growth factor (VEGF) has proven to be the most critical angiogenic factor identified to date, which makes this protein an appropriate target for the inhibition of angiogenesis. Therefore, we hypothesize that the anti-angiogenesis by inhibiting VEGF might be used as an effective strategy for early intervention of hypertrophic scar. Due to the high efficiency and specificity of RNA interference (RNAi) technique, we plan to use the vector-based anti-VEGF RNAi system as a powerful, simple and cost-effective tool in future experimental validation. Our hypothesis, as the first description of anti-VEGF by RNAi technique in controlling hypertrophic scar formation is certainly a vital first step for the establishment of an effective anti-scarring modality. |
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| ISSN: | 1756-2392 |
| DOI: | 10.1016/j.bihy.2008.05.005 |