GABA-A receptors play a minor role in cortical epileptic afterdischarges in immature rats

Abstract The role of inhibitory γ-aminobutyric acid-A (GABA-A) system in the cortical epileptic afterdischarges (ADs) was studied at three different developmental stages of rats. Animals 12, 18 and 25 days old with implanted epidural electrodes were pretreated with bicuculline (1 and 2 mg/kg i.p.) a...

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Bibliographic Details
Published in:Brain research 2011-09, Vol.1412, p.102-107
Main Authors: Tabashidze, N, Mareš, P
Format: Article
Language:English
Subjects:
Animals
Bicuculline
Bicuculline - pharmacology
Biological and medical sciences
brain
Cerebral cortex
Cerebral Cortex - drug effects
Cerebral Cortex - physiopathology
developmental stages
Electric Stimulation
Electrical stimulation
electrodes
Electrodes, Implanted
evoked potentials
Evoked Potentials - drug effects
Evoked Potentials - physiology
GABA Antagonists - pharmacology
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Ontogeny
Rat
Rats
Rats, Wistar
receptors
Receptors, GABA-A - physiology
Seizures
Seizures - physiopathology
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Summary:Abstract The role of inhibitory γ-aminobutyric acid-A (GABA-A) system in the cortical epileptic afterdischarges (ADs) was studied at three different developmental stages of rats. Animals 12, 18 and 25 days old with implanted epidural electrodes were pretreated with bicuculline (1 and 2 mg/kg i.p.) and 15 min later repeatedly stimulated with low frequency trains with stepwise increasing current intensity. Bicuculline only exceptionally decreased threshold current intensities necessary for elicitation of movements directly bound to stimulation, spike-and wave ADs, clonic seizures and transition into a limbic type of ADs. Duration of ADs was not systematically affected by either dose of bicuculline. In contrast, transcallosal evoked potentials exhibited under the influence of bicuculline steeper curve expressing relation between intensity of stimuli and amplitude of responses. In contrast to GABA-B receptors, GABA-A receptors do not play an important role in generation and arrest of cortical epileptic ADs in immature rats.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2011.07.034