Oesophageal eosinophilic infiltration in patients with noncardiac chest pain

Aliment Pharmacol Ther 2011; 33: 1194–1201 Summary Background  Eosinophilic oesophagitis clinically presents with recurrent episodes of dysphagia and food impaction. Recently, we observed patients with noncardiac chest pain and eosinophilic oesophagitis. Aims  To estimate the prevalence of abnormal...

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Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2011-06, Vol.33 (11), p.1194-1201
Main Authors: Achem, S. R., Almansa, C., Krishna, M., Heckman, M. G., Wolfsen, H. C., Talley, N. J., DeVault, K. R.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biopsy
Chest
Chest Pain - etiology
Deglutition Disorders - etiology
Demography
Dysphagia
Endoscopy
Endoscopy, Digestive System - methods
Eosinophilic Esophagitis - complications
Eosinophilic Esophagitis - diagnosis
Esophagus
Esophagus - physiology
Female
Food
Foreign Bodies - etiology
Humans
Hypersensitivity
Leukocytes (eosinophilic)
Male
Middle Aged
Pain
Predictive Value of Tests
Retrospective Studies
Sex Factors
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Summary:Aliment Pharmacol Ther 2011; 33: 1194–1201 Summary Background  Eosinophilic oesophagitis clinically presents with recurrent episodes of dysphagia and food impaction. Recently, we observed patients with noncardiac chest pain and eosinophilic oesophagitis. Aims  To estimate the prevalence of abnormal eosinophilic infiltration in noncardiac chest pain patients and examine diagnostic utility of demographic, clinical and endoscopic variables to predict eosinophilic oesophagitis. Methods  Retrospective study of 171 consecutive patients referred for EGD evaluation of noncardiac chest pain. Endoscopic signs consistent with eosinophilic oesophagitis were recorded. The histological findings were grouped as normal: 0–5 eosinophils/high power field (e/hpf), indeterminate: 6–20 e/hpf, and eosinophilic oesophagitis: ≥21 e/hpf. Abnormal eosinophilic infiltration was defined as ≥6 e/hpf. Results  Abnormal eosinophilic infiltrate was noted in 24 patients (14%). Thirteen (8%) had indeterminate counts, while 11 (6%) had eosinophilic oesophagitis. Compared with normal, those with abnormal oesophageal eosinophilic infiltration were more likely to be male (71% vs. 34%, P = 0.001), have allergies (29% vs. 12%, P = 0.050), have current GER symptoms (42% vs. 18%, P = 0.013), rings (54% vs. 22%, P = 0.002), furrows (21% vs. 1%, P 
ISSN:0269-2813
1365-2036
DOI:10.1111/j.1365-2036.2011.04652.x