MicroRNA-143 functions as a tumor suppressor in human bladder cancer T24 cells

Highlights ► MicroRNA (miR)-143 and -145 were down-regulated in human bladder cancer T24 cells. ► The enforced expression of miR-143 induced growth-suppression in T24 cells. ► The chemically-modified synthetic miR-143 exhibited a greater growth-inhibitory effect than wild-type miR-143. ► The chemica...

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Bibliographic Details
Published in:Cancer letters 2011-08, Vol.307 (2), p.211-220
Main Authors: Noguchi, Syunsuke, Mori, Takashi, Hoshino, Yuki, Maruo, Kohji, Yamada, Nami, Kitade, Yukio, Naoe, Tomoki, Akao, Yukihiro
Format: Article
Language:English
Subjects:
Akt
AKT protein
Apoptosis
Base Sequence
Binding sites
Bladder cancer
Blotting, Western
Cancer
Cancer therapies
Cell death
Cell growth
Cell Line, Tumor
Chemotherapy
Cisplatin
Colorectal cancer
DNA Primers
ERK5
Gene expression
Genomes
Hematology, Oncology and Palliative Medicine
Humans
microRNA
MicroRNA-143
MicroRNAs
MicroRNAs - genetics
MicroRNAs - physiology
miRNA
Proteins
Reverse Transcriptase Polymerase Chain Reaction
Rodents
Science
Translation
Tumor suppressor
Tumor suppressor genes
Urinary bladder
urinary bladder neoplasms
Urinary Bladder Neoplasms - pathology
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Summary:Highlights ► MicroRNA (miR)-143 and -145 were down-regulated in human bladder cancer T24 cells. ► The enforced expression of miR-143 induced growth-suppression in T24 cells. ► The chemically-modified synthetic miR-143 exhibited a greater growth-inhibitory effect than wild-type miR-143. ► The chemically-modified synthetic miR-143 functions as a tumor suppressor in T24 cells by targeting ERK5.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2011.04.005