Acute necrotic stomatitis (noma) associated with methicillin-resistant Staphylococcus aureus infection in a newly acquired rhesus macaque (Macaca mulatta)

Backgroud  A newly acquired rhesus macaque was suffering from rapid destruction of the left cheek caused by necrotizing stomatitis. Methods  To restore reconstructive surgery and intensive care with antibiotics, wound protection, wound healing agents, and debridement were applied. Results  Staphyloc...

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Bibliographic Details
Published in:Journal of medical primatology 2011-06, Vol.40 (3), p.188-193
Main Authors: Lee, J.-I., Kim, K.-S., Oh, B.-C., Kim, N.-A., Kim, I.-H., Park, C.-G., Kim, S.-J.
Format: Article
Language:English
Subjects:
Ampicillin - therapeutic use
Animals
Anti-Bacterial Agents - therapeutic use
Antibiotics
Cheek
Drug resistance
Enterococcus faecalis
Enterococcus faecalis - classification
Enterococcus faecalis - drug effects
Enterococcus faecalis - isolation & purification
Epidermal growth factor
Epidermal Growth Factor - therapeutic use
Gram-Positive Bacterial Infections - drug therapy
Gram-Positive Bacterial Infections - microbiology
Gram-Positive Bacterial Infections - surgery
Humans
Infection
Macaca mulatta
Male
methicillin-resistant Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus - classification
Methicillin-Resistant Staphylococcus aureus - drug effects
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Monkey Diseases - drug therapy
Monkey Diseases - microbiology
Monkey Diseases - surgery
Mouth - pathology
Mouth - surgery
Necrosis - drug therapy
Necrosis - microbiology
Necrosis - surgery
Necrosis - veterinary
Noma
Noma - drug therapy
Noma - microbiology
Noma - surgery
Noma - veterinary
Oral Surgical Procedures - veterinary
Primates
recombinant human epidermal growth factor
Reconstructive Surgical Procedures - veterinary
rhesus macaque
Staphylococcal Infections - drug therapy
Staphylococcal Infections - microbiology
Staphylococcal Infections - surgery
Staphylococcal Infections - veterinary
Staphylococcus aureus
Stomatitis
Stomatitis - drug therapy
Stomatitis - microbiology
Stomatitis - surgery
Stomatitis - veterinary
Sulbactam - therapeutic use
Surgery
Topical application
Vancomycin
Vancomycin - therapeutic use
Wound Healing
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Summary:Backgroud  A newly acquired rhesus macaque was suffering from rapid destruction of the left cheek caused by necrotizing stomatitis. Methods  To restore reconstructive surgery and intensive care with antibiotics, wound protection, wound healing agents, and debridement were applied. Results  Staphylococcus aureus and Enterococcus faecalis were isolated from the culture of the lesion, and the antibiotic susceptibility test revealed methicillin‐resistant Staphylococcus aureus infection. Vancomycin and ampicillin‐sulbactam effectively treated the bacterial infections, and reconstructive surgery was performed once the infection was cleared. Topical application of recombinant human epidermal growth factor (rhEGF) was useful to treat exposed wound of the noma lesion. Conclusions  Simian noma associated with methicillin‐resistant Staphylococcus aureus (MRSA) had not previously been reported in non‐human primates. Although noma associated with MRSA is hard to cure because of its rapid and destructive progress, the aggressive therapy used in this study led to the successful resolution of an acute necrotic stomatitis lesion in a rhesus macaque.
ISSN:0047-2565
1600-0684
DOI:10.1111/j.1600-0684.2011.00470.x