Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?

Auditory P50 sensory gating deficits correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The well-supported role of catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF) and neuregulin 1 (NRG1) genes in neurodevelopment and...

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Bibliographic Details
Published in:Psychological medicine 2011-02, Vol.41 (2), p.263-276
Main Authors: Shaikh, M., Hall, M.-H., Schulze, K., Dutt, A., Walshe, M., Williams, I., Constante, M., Picchioni, M., Toulopoulou, T., Collier, D., Rijsdijk, F., Powell, J., Arranz, M., Murray, R. M., Bramon, E.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Aged
Biological and medical sciences
Brain-Derived Neurotrophic Factor - genetics
Catechol O-Methyltransferase - genetics
Cognition
Endophenotypes
Evoked Potentials, Auditory - genetics
Family Health
Female
Genes
Genetic susceptibility
Genotype & phenotype
Humans
Linear Models
Linear regression analysis
Logistic Models
Male
Medical sciences
Middle Aged
Neuregulin-1 - genetics
Other psychotic disorders
Polymorphism
Polymorphism, Genetic
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Psychosis
Psychotic Disorders - genetics
Risk factors
Schizophrenia
Sensory perception
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Summary:Auditory P50 sensory gating deficits correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The well-supported role of catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF) and neuregulin 1 (NRG1) genes in neurodevelopment and cognition make a strong theoretical case for their influence on the P50 endophenotype. The possible role of NRG1, COMT Val158Met and BDNF Val66Met gene polymorphisms on the P50 endophenotype was examined in a large sample consisting of psychotic patients, their unaffected relatives and unrelated healthy controls using linear regression analyses. Although P50 deficits were present in patients and their unaffected relatives, there was no evidence for an association between NRG1, COMT Val158Met or BDNF Val66Met genotypes and the P50 endophenotype. The evidence from our large study suggests that any such association between P50 indices and NRG1, COMT Val158Met or BDNF Val66Met genotypes, if present, must be very subtle.
ISSN:0033-2917
1469-8978
DOI:10.1017/S003329170999239X