Pathological and mammographic prognostic factors for screen detected cancers in a multi-centre randomised, controlled trial of mammographic screening in women from age 40 to 48 years

Abstract Aim To assess pathological and radiological prognostic factors for cancers detected by screening within a multi-centre RCT trial of mammographic screening of younger women. Method The survival of 232 women with screen detected invasive cancer was ascertained. Data on invasive cancer size, h...

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Published in:	Breast (Edinburgh) 2011-12, Vol.20 (6), p.525-528
Main Authors:	Bennett, R.L, Evans, A.J, Kutt, E, Record, C, Bobrow, L.G, Ellis, I.O, Hanby, A, Moss, S.M
Format:	Article
Language:	eng
Subjects:	Adult Breast Neoplasms - diagnostic imaging Breast Neoplasms - mortality Breast Neoplasms - pathology Comedo calcification England - epidemiology Female Hematology, Oncology and Palliative Medicine Humans Lymphatic Metastasis Mammography Middle Aged Pathology Prognosis Randomised controlled trial Screening Survival Analysis Treatment Outcome
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Summary:	Abstract Aim To assess pathological and radiological prognostic factors for cancers detected by screening within a multi-centre RCT trial of mammographic screening of younger women. Method The survival of 232 women with screen detected invasive cancer was ascertained. Data on invasive cancer size, histological grade, nodal status, vascular invasion, mammographic spiculation, comedo calcification and mammographic background were assessed. Kaplan–Meier and Cox proportional hazards methods were used to examine survival. Results Univariate analysis indicated that women with cancers with the following features had poorer survival; ≥30 mm, histologically grade 3, heavily node positive (4 or more positive nodes), vascular invasion positive and displaying mammographic comedo calcification. In a multivariate model survival remained poorer in women with four or more nodes positive (HR 8.36, 95% CI 2.31, 30.17) and in those with comedo calcification (HR 3.00,95% CI 1.13, 7.99). Conclusion Nodal status and the presence of mammographic comedo calcification have independent prognostic significance in young women with screen detected cancer.
ISSN:	0960-9776 1532-3080