Sustained seroconversion of chronic hepatitis B infection after stem cell transplantation

Serap A, Funda O, Bengu K, Mehmet K, Nazan C, Rasit Y, Savas K. Sustained seroconversion of chronic hepatitis B infection after stem cell transplantation.
Pediatr Transplantation 2011: 15: E92–E95. © 2010 John Wiley & Sons A/S. :  We present an 18‐yr‐old adolescent with acute lymphocytic leukemi...

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Bibliographic Details
Published in:Pediatric transplantation 2011-08, Vol.15 (5), p.E92-E95
Main Authors: Serap, Aksoylar, Funda, Ozgenc, Bengu, Kadioglu, Mehmet, Kantar, Nazan, Cetingul, Rasit, Yagci, Savas, Kansoy
Format: Article
Language:English
Subjects:
Adaptive Immunity
Adolescence
Adolescent
adoptive immunity transfer
Chronic infection
Donors
Graft vs Host Disease
Graft-versus-host reaction
Hepatitis B
Hepatitis B virus
Hepatitis B virus - genetics
Hepatitis B, Chronic - complications
Hepatitis B, Chronic - virology
Histocompatibility antigen HLA
Humans
Immunity
Immunosuppressive Agents - therapeutic use
Immunotherapy - methods
Lamivudine
Lamivudine - therapeutic use
Lymphatic leukemia
Male
Peripheral blood
Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
Risk
Seroconversion
stem cell transplantation
Stem Cell Transplantation - methods
Treatment Outcome
Viral Load
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Summary:Serap A, Funda O, Bengu K, Mehmet K, Nazan C, Rasit Y, Savas K. Sustained seroconversion of chronic hepatitis B infection after stem cell transplantation.
Pediatr Transplantation 2011: 15: E92–E95. © 2010 John Wiley & Sons A/S. :  We present an 18‐yr‐old adolescent with acute lymphocytic leukemia, who underwent peripheral blood SCT with serologically and histologically documented chronic hepatitis B infection. Prior and during the transplant process, lamivudine was administered orally and he underwent SCT with a twofold decrease in viral load at the time of transplant from his HLA full matched, HBV natural immune (anti‐HBs and anti‐HBc positive) donor. Successful engraftment was achieved and three months after SCT, HBV seroconversion was documented accompanied with an ALT flare. Chronic graft‐versus‐host disease coincided after the transplantation, and he has been on immunosuppressive treatment for 25 months with sustained HBV seroconversion. We assume that adoptive immunity transfer combined with antiviral treatment might also constitute sustained seroconversion in chronic HBV, besides the reported risk of reactivation.
ISSN:1397-3142
1399-3046
DOI:10.1111/j.1399-3046.2009.01272.x