Detection of human papilloma virus in normal skin and in superficial and nodular basal cell carcinomas in immunocompetent subjects

Background  Human papilloma virus (HPV) is increasingly recognized as an important human carcinogen but its role in the aetiopathogenesis of basal cell carcinoma (BCC) in immunocompetent individuals is unclear. Objective  A prospective case–control study was designed to compare the prevalence of HPV...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the European Academy of Dermatology and Venereology 2011-07, Vol.25 (7), p.832-838
Main Authors: Escutia, B., Ledesma, E., Serra-Guillen, C., Gimeno, C., Vilata, J.J., Guillén, C., Nagore, E.
Format: Article
Language:English
Subjects:
Aged
Aging
basal cell
Basal cells
Carcinogens
Carcinoma
Carcinoma, Basal Cell - virology
Data processing
Female
Geriatrics
Human papillomavirus
Humans
Immunocompetence
Infection
Keratosis
Male
Middle Aged
Multivariate analysis
Papillomaviridae - isolation & purification
papillomavirus infections
Polymerase chain reaction
Risk factors
Skin
Skin - virology
skin neoplasms
Skin Neoplasms - virology
Statistical analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background  Human papilloma virus (HPV) is increasingly recognized as an important human carcinogen but its role in the aetiopathogenesis of basal cell carcinoma (BCC) in immunocompetent individuals is unclear. Objective  A prospective case–control study was designed to compare the prevalence of HPV in BCC and normal skin samples from immunocompetent subjects and to assess the influence of different clinical features on the risk of cutaneous HPV. Methods  A total of 142 samples from 70 BCC cases (superficial BCC 38 and nodular BCC 32) and 72 controls were analysed by a degenerated nested PCR technique. Clinical data were recorded and risk factors for HPV infection were assessed by multivariate analysis. Results  There were 31 HPV DNA‐positive samples. HPV was detected more frequently in cases (25.7%) than in controls (18.1%) and in nodular (31.3%) than in superficial (21.1%) BCC lesions but differences were not statistically significant. Older age (OR 1.5; 95% CI: 1.02–1.09) and actinic keratosis (OR 2.62; 95% CI 1.15–5.96) were the only significant factors associated to the presence of HPV. Risk of HPV positivity was also higher in blond‐haired subjects, fair/pale skin colour, history of sunburn, solar lentigines and seborrheic keratosis but the differences were not significant. Both in cases and controls, β ‐types were the most frequent. Conclusions  HPV does not seem to play a fundamental role in the aetiopathogenesis of either nodular or superficial BCC. The presence of HPV appears to be more related to actinic damage and possibly to an alteration of the barrier function associated with ageing.
ISSN:0926-9959
1468-3083
DOI:10.1111/j.1468-3083.2010.03875.x