Characterization of the chemically deposited hydroxyapatite coating on a titanium substrate

Bioactive hydroxyapatite (HA) coating on titanium (Ti) implant can be used as a drug delivery device. A controlled release of drug around the implant requires the incorporation of drug into the coating material during the coating process. HA coating was prepared using a two-step procedure in conditi...

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Bibliographic Details
Published in:	Journal of materials science. Materials in medicine 2011, Vol.22 (1), p.1-9
Main Authors:	Zavgorodniy, Alexander V., Borrero-López, Oscar, Hoffman, Mark, LeGeros, Racquel Z., Rohanizadeh, Ramin
Format:	Article
Language:	eng
Subjects:	Biological and medical sciences Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Bone Morphogenetic Protein 2 - administration & dosage Bone Morphogenetic Protein 2 - pharmacokinetics Ceramics Chemistry and Materials Science Coated Materials, Biocompatible - analysis Coated Materials, Biocompatible - chemical synthesis Coated Materials, Biocompatible - chemistry Coated Materials, Biocompatible - metabolism Composites Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug Carriers - metabolism Drug delivery systems Durapatite - analysis Durapatite - chemistry Durapatite - pharmacokinetics Elastic Modulus Electroplating - methods Glass Hardness Tests Humans Hydroxyapatite Materials Science Materials Testing Medical sciences Microscopy, Electron, Scanning Models, Biological Natural Materials Polymer Sciences Regenerative Medicine/Tissue Engineering Shear stress Spectroscopy, Fourier Transform Infrared Surface Properties Surfaces and Interfaces Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Thin Films Titanium - chemistry Titanium - metabolism X-Ray Diffraction
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Summary:	Bioactive hydroxyapatite (HA) coating on titanium (Ti) implant can be used as a drug delivery device. A controlled release of drug around the implant requires the incorporation of drug into the coating material during the coating process. HA coating was prepared using a two-step procedure in conditions suitable for simultaneous incorporation of the protein-based drug into the coating material. Monetite coating was deposited on Ti substrate in acidic condition followed by the transformation of the monetite coating to HA. X-ray diffraction (XRD) confirmed the formation of the monetite phase at the first step of the coating preparation, which was transformed into HA at the second step. Fourier transform infrared spectroscopy demonstrated typical bands of a crystallized carbonated HA with A- and B-type substitution, which was confirmed by the XRD refinement of the structural parameters. Scanning electron microscope was used to observe the morphology of monetite and HA coatings. Adhesion of the coatings was measured using a scratch tester. The critical shearing stress was found to be 84.20 ± 1.27 MPa for the monetite coating, and 44.40 ± 2.39 MPa for the HA coating.
ISSN:	0957-4530 1573-4838