Adenosine A sub(2A) receptor imaging with [ super(11)C]KF18446 PET in the rat brain after quinolinic acid lesion: Comparison with the dopamine receptor imaging

We proposed [ super(11)C]KF18446 as a selective radioligand for mapping the adenosine A sub(2A) receptors being highly enriched in the striatum by positron emission tomography (PET). In the present study, we investigated whether [ super(11)C]KF18446 PET can detect the change in the striatal adenosin...

Full description

Saved in:
Bibliographic Details
Published in:Annals of nuclear medicine 2002-11, Vol.16 (7), p.467-475
Main Authors: Ishiwata, Kiichi, Ogi, Nobuo, Hayakawa, Nobutaka, Oda, Keiichi, Nagaoka, Tsukasa, Toyama, Hinako, Suzuki, Fumio, Endo, Kazutoyo, Tanaka, Akira, Senda, Michio
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We proposed [ super(11)C]KF18446 as a selective radioligand for mapping the adenosine A sub(2A) receptors being highly enriched in the striatum by positron emission tomography (PET). In the present study, we investigated whether [ super(11)C]KF18446 PET can detect the change in the striatal adenosine A sub(2A) receptors in the rat after unilateral injection of an excitotoxin quinolinic acid into the striatum, a Huntington's disease model, to demonstrate the usefulness of [ super(11)C]KF18446. The extent of the striatal lesion was identified based on MRI, to which the PET was co-registered. The binding potential of [ super(11)C]KF18446 significantly decreased in the quinolinic acid-lesioned striatum. The decrease was comparable to the decrease in the potential of [ super(11)C]raclopride binding to dopamine D sub(2) receptors in the lesioned striatum, but seemed to be larger than the decrease in the potential of [ super(11)C]SCH 23390 binding to dopamine D sub(1) receptors.Ex vivo andin vitro autoradiography validated the PET signals. We concluded that [ super(11)C]KF18446 PET can detect change in the adenosine A sub(2A) receptors in the rat model, and will provide a new diagnostic tool for characterizing post-synaptic striatopallidal neurons in the stratum.
ISSN:0914-7187
1864-6433
DOI:10.1007/BF02988643