Hexokinase-II expression in untreated oral squamous cell carcinoma: comparison with FDG PET imaging

Hexokinase is thought to be one of the key factors of glucose catabolism in the cell. The aim of this study was to investigate the relationship between HK-II expression and 18F-fluoro-2-deoxy-D-glucose (FDG) uptake in human untreated oral squamous cell carcinoma (OSCC). Pre-operatively FDG positron...

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Bibliographic Details
Published in:Annals of nuclear medicine 2005-06, Vol.19 (4), p.335-338
Main Authors: Tian, Mei, Zhang, Hong, Higuchi, Tetsuya, Oriuchi, Noboru, Nakasone, Yoshiki, Takata, Kuniaki, Nakajima, Nobuaki, Mogi, Kenji, Endo, Keigo
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers, Tumor - metabolism
Carcinoma, Squamous Cell - diagnostic imaging
Carcinoma, Squamous Cell - metabolism
Catabolism
Female
Fluorodeoxyglucose F18 - pharmacokinetics
Glucose
Hexokinase
Hexokinase - metabolism
Humans
Male
Middle Aged
Mouth Neoplasms - diagnostic imaging
Mouth Neoplasms - metabolism
Oral cancer
Oral carcinoma
Oral squamous cell carcinoma
Positron emission
Positron emission tomography
Positron-Emission Tomography - methods
Radiopharmaceuticals - pharmacokinetics
Reproducibility of Results
Sensitivity and Specificity
Skin cancer
Squamous cell carcinoma
Statistical analysis
Statistics as Topic
Tumors
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Summary:Hexokinase is thought to be one of the key factors of glucose catabolism in the cell. The aim of this study was to investigate the relationship between HK-II expression and 18F-fluoro-2-deoxy-D-glucose (FDG) uptake in human untreated oral squamous cell carcinoma (OSCC). Pre-operatively FDG positron emission tomography (PET) was performed 60 min after FDG injection in all the patients. Maximum standardized uptake value (SUV) was used for evaluation of tumor FDG uptake. Tumor sections were stained immunohistochemically for HK-II. All the tumor sections stained positive for HK-II. Eighteen (95%) tumors in HK-II showed immunostained positive area >50%. HK-II findings revealed eleven (58%) tumors with strong intensity, six (32%) with moderate intensity and two with weak intensity (10%). There was no statistically significant correlation between SUV and the expression of HK-II (p = 0.46). In conclusion, OSCC showed increased FDG accumulation and overexpression of HK-II. However, we did not find any significant relationship between high FDG uptake and overexpression of HK-II in this patient population, and thus other properties need to be evaluated in order to elucidate key factors responsible for FDG activity in OSCC.
ISSN:0914-7187
1864-6433
DOI:10.1007/BF02984629