Homocysteine and hypertension in persons with spinal cord injury

Cross-sectional analysis of a convenience sample of locally recruited participants, including both patients and volunteers. To determine whether there is an association between plasma homocysteine and hypertension in persons with spinal cord injury (SCI). Spinal Cord Injury Service of the Veterans A...

Full description

Saved in:
Bibliographic Details
Published in:Spinal cord 2006-08, Vol.44 (8), p.474-479
Main Authors: LEE, M. Y, MYERS, J, ABELLA, J, FROELICHER, V. F, PERKASH, I, KIRATLI, B. J
Format: Article
Language:English
Subjects:
Age Distribution
Biological and medical sciences
California - epidemiology
Cerebrospinal fluid. Meninges. Spinal cord
Cerebrospinal fluid. Spinal cord. Spinal roots. Spinal nerves
Female
Homocysteine - blood
Humans
Hypertension - blood
Hypertension - epidemiology
Incidence
Injuries of the nervous system and the skull. Diseases due to physical agents
Kidney Diseases - blood
Kidney Diseases - epidemiology
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Neurosurgery
Risk Assessment - methods
Risk Factors
Spinal Cord Injuries - blood
Spinal Cord Injuries - epidemiology
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Traumas. Diseases due to physical agents
Veterans - statistics & numerical data
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cross-sectional analysis of a convenience sample of locally recruited participants, including both patients and volunteers. To determine whether there is an association between plasma homocysteine and hypertension in persons with spinal cord injury (SCI). Spinal Cord Injury Service of the Veterans Affairs Palo Alto Medical Center (California, United States of America). The incidence of hypertension, dyslipidemia, insulin resistance, and the presence of metabolic syndrome were determined in 168 individuals with SCI (mean age 50.2 +/- 12.8 years). Fasting lipids, insulin, glucose, plasma homocysteine, and anthropometric data was gathered for each subject. Blood pressure values (P < 0.001) and mean arterial pressure (P < 0.05) increased with higher plasma homocysteine levels. Homocysteine values were also significantly greater among individuals with hypertension compared with those who were normotensive or prehypertensive (P < 0.0001). There was an inverse relationship between plasma homocysteine levels and glomerular filtration rate and effective renal plasma flow (P < 0.05). Plasma homocysteine levels are elevated in persons with SCI who have hypertension and inversely related to renal function, which suggests that renal dysfunction may be a link between homocysteine and hypertension in persons with SCI. Funded by the VA Rehabilitation Research and Development Service, Merit Review Grant #B2549R.
ISSN:1362-4393
1476-5624
DOI:10.1038/sj.sc.3101873