A Review of the Role of Mechanical Forces in Cutaneous Wound Healing

Cutaneous wound healing is a complex process with many types of mechanical forces regulating the quality and speed of healing. The role of mechanical forces in regulating tissue growth, repair and remodelling was recognised more than a century ago. Such forces influence gene expression, the synthesi...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of surgical research 2011-12, Vol.171 (2), p.700-708
Main Authors: Agha, Riaz, M.B.B.S., M.R.C.S., M.R.C.S.Ed, Ogawa, Rei, M.D., Ph.D, Pietramaggiori, Giorgio, M.D., Ph.D, Orgill, Dennis P., M.D., Ph.D
Format: Article
Language:English
Subjects:
angiogenesis
Animals
Biological and medical sciences
cutaneous
Dermatology
General aspects
Humans
Keloid - physiopathology
keloid hypertrophic scarring
Medical sciences
micromechanical forces
Neovascularization, Physiologic - physiology
Skin - blood supply
Skin - injuries
Skin involvement in other diseases. Miscellaneous. General aspects
Skin Physiological Phenomena
Stress, Mechanical
Surgery
VAC
wound healing
Wound Healing - physiology
wound tension
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cutaneous wound healing is a complex process with many types of mechanical forces regulating the quality and speed of healing. The role of mechanical forces in regulating tissue growth, repair and remodelling was recognised more than a century ago. Such forces influence gene expression, the synthesis of growth factors and inflammatory mediators and cellular processes like proliferation of many load-sensitive cells. However, the exact mechanisms by which these forces interact with cells and ways to use them to stimulate tissues are still active research fronts. This article sets to review the literature on mechanical forces and their role in cutaneous wound healing.
ISSN:0022-4804
1095-8673
DOI:10.1016/j.jss.2011.07.007