Effect of copper intrauterine device on the cyclooxygenase and inducible nitric oxide synthase expression in the luteal phase endometrium

Abstract Background To evaluate the effect of copper intrauterine device (IUD) on the expression of cyclooxygenase (COX) and inducible nitric oxide synthase (iNOS) in the luteal phase endometrium. Study Design A prospective clinical study was conducted on 30 women who were willing to use a copper IU...

Full description

Saved in:
Bibliographic Details
Published in:Contraception (Stoneham) 2011-12, Vol.84 (6), p.637-641
Main Authors: Coskun, Ebru, Cakiroglu, Yigit, Aygun, Banu Kumbak, Muezzinoglu, Bahar, Caliskan, Eray
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
COX-2
Cyclooxygenase 2 - metabolism
Dysmenorrhea
Dysmenorrhea - etiology
Dysmenorrhea - physiopathology
Endometrium - enzymology
Endometrium - metabolism
Epithelium - enzymology
Epithelium - metabolism
Female
Female genital diseases
Genital system. Reproduction
Gynecology. Andrology. Obstetrics
Humans
iNOS
Intrauterine Devices, Copper - adverse effects
Luteal Phase - metabolism
Medical sciences
Menorrhagia - etiology
Menorrhagia - physiopathology
Menstrual abnormalities
Nitric Oxide Synthase Type II - metabolism
Non tumoral diseases
Obstetrics and Gynecology
Pharmacology. Drug treatments
Pulsatile Flow
Regional Blood Flow
TCu380A
Time Factors
Ultrasonography, Doppler, Color
Uterine Artery - diagnostic imaging
Uterine Artery - physiology
Uterine Artery - physiopathology
Vascular Resistance
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background To evaluate the effect of copper intrauterine device (IUD) on the expression of cyclooxygenase (COX) and inducible nitric oxide synthase (iNOS) in the luteal phase endometrium. Study Design A prospective clinical study was conducted on 30 women who were willing to use a copper IUD contraception. Endometrial biopsies and blood samples were taken before and 3 months after the insertion of the IUD on Day 3 and Days 20–24 of the cycle. Main outcome measures were to evaluate the effect of copper IUD on uterine artery blood flow using pulsed color Doppler ultrasonography and the relationship of bleeding abnormalities and menstrual pain level with the uterine blood flow, COX-2 and iNOS expression. Results Only the left uterine artery pulsatility and resistance indices decreased statistically significantly (p=.005 and p=.039, respectively). Other Doppler parameters showed no change. Cyclooxygenase-2 expression of both endometrial luminal epithelium (p=.03) and gland epithelium (p=.03) increased significantly. Inducible NOS expression of the endometrial surface epithelium decreased significantly after IUD insertion (p=.01). Conclusions Although COX-2 expression increased 3 months after copper IUD insertion, iNOS expression of the luminal epithelium decreased. Local hypoxia caused by copper and vasoconstrictor prostanoids may play a role in IUD-related menstrual abnormalities.
ISSN:0010-7824
1879-0518
DOI:10.1016/j.contraception.2011.03.027