Enantioselective organocatalytic asymmetric allylic alkylation. Bis(phenylsulfonyl)methane addition to MBH carbonates

The highly enantioselective asymmetric allylic alkylation of Morita-Baylis-Hillman carbonates with bis(phenylsulfonyl)methane is presented. The reaction is simply catalyzed by cinchona alkaloid derivatives affording the final alkylated products in good yields and enantioselectivities.

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2011-12, Vol.9 (23), p.7986-7989
Main Authors: Companyó, Xavier, Valero, Guillem, Ceban, Victor, Calvet, Teresa, Font-Bardía, Mercé, Moyano, Albert, Rios, Ramon
Format: Article
Language:English
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Summary:The highly enantioselective asymmetric allylic alkylation of Morita-Baylis-Hillman carbonates with bis(phenylsulfonyl)methane is presented. The reaction is simply catalyzed by cinchona alkaloid derivatives affording the final alkylated products in good yields and enantioselectivities.
ISSN:1477-0520
1477-0539
DOI:10.1039/c1ob06308a