Distribution of induced chromosome rearrangement breakpoints along the chromosome length and the problem of intercalary heterochromatin in Drosophila melanogaster

Historically, the term “intercalary heterochromatin” was based on the finding that induced chromosome rearrangements occur at a higher frequency in the corresponding regions. The available molecular genetic data and, in particular, the results of the Drosophila Genome Project made it possible to dec...

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Bibliographic Details
Published in:Russian journal of genetics 2008-06, Vol.44 (6), p.646-650
Main Authors: Volkova, E. I., Belyakin, S. N., Belyaeva, E. S., Zhimulev, I. F.
Format: Article
Language:English
Subjects:
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
Drosophila melanogaster
Human Genetics
Microbial Genetics and Genomics
Reviews and Theoretical Articles
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Summary:Historically, the term “intercalary heterochromatin” was based on the finding that induced chromosome rearrangements occur at a higher frequency in the corresponding regions. The available molecular genetic data and, in particular, the results of the Drosophila Genome Project made it possible to decide between two possible explanations of the preferential location of chromosome rearrangement breakpoints in intercalary heterochromatin regions. Namely, a higher frequency of radiation-induced rearrangements in these regions correlates with the DNA content and probably lacks an association with the features of chromatin organization.
ISSN:1022-7954
1608-3369
DOI:10.1134/S1022795408060033