Preclinical renal cancer chemopreventive efficacy of geraniol by modulation of multiple molecular pathways

Graphical abstract Diagrammatic presentation of the hypothesis of the article in a concise manner. It reveals the chemopreventive efficacy of GOH possibly through the modulation of multiple molecular targets. GOH inhibits ROS generation, NFκB and PCNA expression thereby abrogating inflammation and p...

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2011-11, Vol.290 (1), p.69-81
Main Authors: Ahmad, Shiekh Tanveer, Arjumand, Wani, Seth, Amlesh, Nafees, Sana, Rashid, Summya, Ali, Nemat, Sultana, Sarwat
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Apoptosis
Biological and medical sciences
biomarkers
blood serum
carcinogenesis
Carcinogenesis, carcinogens and anticarcinogens
Cell proliferation
Chemical agents
chemoprevention
Drug Evaluation, Preclinical - methods
Emergency
enzyme activity
Ferric Compounds - toxicity
Ferric nitrilotriacetate
Geraniol
inflammation
kidney neoplasms
Kidney Neoplasms - chemically induced
Kidney Neoplasms - metabolism
Kidney Neoplasms - prevention & control
Kidneys
Male
Medical sciences
Nephrology. Urinary tract diseases
nephrotoxicity
Nitrilotriacetic Acid - analogs & derivatives
Nitrilotriacetic Acid - toxicity
oral administration
oxidative stress
proliferating cell nuclear antigen
Rats
Rats, Wistar
Renal carcinogenesis
Signal Transduction - drug effects
Signal Transduction - physiology
Terpenes - pharmacology
Terpenes - therapeutic use
Toxicology
transcription (genetics)
Treatment Outcome
tumor suppressor genes
Tumors
Tumors of the urinary system
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Summary:Graphical abstract Diagrammatic presentation of the hypothesis of the article in a concise manner. It reveals the chemopreventive efficacy of GOH possibly through the modulation of multiple molecular targets. GOH inhibits ROS generation, NFκB and PCNA expression thereby abrogating inflammation and proliferation of tubular cells of kidney. Whereas, GOH induces effector caspase-3 expression both through mitochondrial signalling pathway and death receptor signalling pathway. Highlights ► Geraniol modulates renal carcinogenesis in Wistar rats. ► It abrogates Fe-NTA induced oxidative stress, inflammation and hyperproliferation. ► Promotes apoptosis via induction of both mitochondrial and death receptor pathway. ► Thus, inhibits renal carcinogenesis by modulating multiple molecular targets.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2011.08.020