Anti-inflammatory and analgesic activity of protocatechuic acid in rats and mice

Anti-inflammatory and analgesic activity of protocatechuic acid (PCA), a natural product, was evaluated in different rat models (viz., carrageenan-induced paw oedema, cotton pellet-induced granuloma and Freund’s adjuvant arthritis) of inflammation and chemical and heat induced mouse models of pain....

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Bibliographic Details
Published in:Inflammopharmacology 2011-10, Vol.19 (5), p.255-263
Main Authors: Lende, Amol B., Kshirsagar, Ajay D., Deshpande, Avinash D., Muley, Milind M., Patil, Rajesh Ramesh, Bafna, Pallavi A., Naik, Suresh R.
Format: Article
Language:English
Subjects:
Acetic Acid - toxicity
Allergology
Analgesics - pharmacology
Analgesics - therapeutic use
Analgesics - toxicity
Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Anti-Inflammatory Agents - toxicity
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Anti-Inflammatory Agents, Non-Steroidal - toxicity
Antioxidants - pharmacology
Antioxidants - therapeutic use
Antioxidants - toxicity
Arthritis, Experimental - drug therapy
Biomedical and Life Sciences
Biomedicine
Carrageenan - toxicity
Catalase - metabolism
Dermatology
Diclofenac - pharmacology
Diclofenac - toxicity
Disease Models, Animal
Drug Evaluation, Preclinical
Edema - chemically induced
Edema - drug therapy
Edema - metabolism
Female
Freund's Adjuvant - toxicity
Gastroenterology
Glutathione - metabolism
Granuloma - chemically induced
Granuloma - drug therapy
Granuloma - metabolism
Hydroxybenzoates - pharmacology
Hydroxybenzoates - therapeutic use
Hydroxybenzoates - toxicity
Immunology
Inflammation - chemically induced
Inflammation - drug therapy
Lipid Peroxidation - drug effects
Male
Mice
Nitric Oxide - metabolism
Pain - chemically induced
Pain - drug therapy
Pharmacology/Toxicology
Rats
Rats, Inbred WF
Research Article
Rheumatology
Superoxide Dismutase - metabolism
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Summary:Anti-inflammatory and analgesic activity of protocatechuic acid (PCA), a natural product, was evaluated in different rat models (viz., carrageenan-induced paw oedema, cotton pellet-induced granuloma and Freund’s adjuvant arthritis) of inflammation and chemical and heat induced mouse models of pain. Treatment with PCA inhibited significantly different biological parameters like hind paw oedema, granuloma exudates formation and arthritis index in carrageenan oedema, cotton pellet granuloma and Freund’s adjuvant arthritis, respectively. The biochemical changes viz., glutathione, superoxide dismutase, catalase, lipid peroxidation and NO in oedematous or in liver tissues and serum alanine aminotransferase and lactic dehydrogenase occurred during different types of inflammation were either significantly restored or inhibited with PCA pretreatment. Present experimental findings demonstrate promising anti-inflammatory and analgesic activity of PCA which is comparable with that of standard drugs used.
ISSN:0925-4692
1568-5608
DOI:10.1007/s10787-011-0086-4