Detecting putative recombination events of hepatitis B virus： An updated comparative genome analysis

An updated collection of 791 human hepatitis B virus （HBV） genomes and 38 non-human primate HBV genomes was analyzed for identifying putative recombination events and their recombinants by using two bioinformatics software tools： Simplot and RDP3 with five algorithms （RDP, GENECONV, MaxChi, Chimaera...

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Bibliographic Details
Published in:Chinese science bulletin 2010-08, Vol.55 (22), p.2373-2379
Main Authors: Ye, Lin, Zhang, Yuan, Mei, Yi, Nan, Peng, Zhong, Yang
Format: Article
Language:English
Subjects:
Algorithms
Chemistry/Food Science
Earth Sciences
Engineering
Hepatitis B virus
Humanities and Social Sciences
Life Sciences
multidisciplinary
Physics
Science
Science (multidisciplinary)
乙型肝炎病毒
乙肝病毒
基因组分析
灵长目动物
生物信息学
重组体
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Summary:An updated collection of 791 human hepatitis B virus （HBV） genomes and 38 non-human primate HBV genomes was analyzed for identifying putative recombination events and their recombinants by using two bioinformatics software tools： Simplot and RDP3 with five algorithms （RDP, GENECONV, MaxChi, Chimaera, and SiScan）. A total of 61 recombinants from nine putative recombination events were detected with RDP3, especially the breakpoints of six events which have both two parental sequences that can be determined precisely with Simplot. To our knowledge, 53 recombinants were found for the first time. Our study also suggests that a relatively high recombination frequency occurs in the PreC/C gene region and the position near gene boundaries.
ISSN:1001-6538
1861-9541
DOI:10.1007/s11434-010-3109-4