Food hypersensitivity reactions in Soft Coated Wheaten Terriers with protein-losing enteropathy or protein-losing nephropathy or both: gastroscopic food sensitivity testing, dietary provocation, and fecal immunoglobulin E

The purpose of this study was to evaluate Soft Coated Wheaten Terriers (SCWTs) affected with protein‐losing enteropathy (PLE) or protein‐losing nephropathy (PLN) or both for allergy to food. We performed gastroscopic food‐sensitivity testing, a provocative dietary trial, and measurement of fecal imm...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 2000, Vol.14 (1), p.60-67
Main Authors: Vaden, S.L, Hammerberg, B, Davenport, D.J, Orton, S.M, Trogdon, M.M, Melgarejo, L.T, VanCamp, S.D, Williams, D.A
Format: Article
Language:English
Subjects:
allergic reactions
Animals
creatinine
digestive system diseases
Dog Diseases - immunology
Dogs
endoscopy
eosinophils
Feces - chemistry
feces composition
Female
food allergies
Food allergy
Food Hypersensitivity - complications
Food Hypersensitivity - immunology
Food Hypersensitivity - veterinary
gastric mucosa
globulins
Glomerulonephritis
Glomerulonephritis - etiology
Glomerulonephritis - immunology
Glomerulonephritis - veterinary
glomerulopathy
immunoglobulin E
Immunoglobulin E - analysis
Inflammatory bowel disease
Inflammatory Bowel Diseases - immunology
Inflammatory Bowel Diseases - veterinary
Male
protein depletion
Protein-Losing Enteropathies - etiology
Protein-Losing Enteropathies - immunology
Protein-Losing Enteropathies - veterinary
proteinase inhibitors
proteinuria
ratios
serum albumin
Syndrome
terriers
Triticum aestivum
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Summary:The purpose of this study was to evaluate Soft Coated Wheaten Terriers (SCWTs) affected with protein‐losing enteropathy (PLE) or protein‐losing nephropathy (PLN) or both for allergy to food. We performed gastroscopic food‐sensitivity testing, a provocative dietary trial, and measurement of fecal immunoglobulin E (IgE) in 6 SCWTs affected with PLE or PLN or both. Positive gastroscopic food‐sensitivity test reactions were noted in 5 of 6 dogs. Positive reactions were found to milk in 4 dogs, to lamb in 2 dogs, and to wheat and chicken each in 1 dog. Adverse reactions to food (diarrhea, vomiting, or pruritus) were detected in all 6 dogs during the provocative dietary trial. Adverse reactions were found to corn in 5 dogs, to tofu in 3 dogs, to cottage cheese in 2 dogs, to milk in 2 dogs, to farina cream of wheat in 2 dogs, and to lamb in 2 dogs. Serum albumin concentrations significantly decreased and fecal α1‐protease inhibitor concentration significantly increased 4 days after the provocative trial when compared with baseline values. Antigen‐specific fecal IgE varied throughout the provocative trial, with peak levels following ingestion of test meals. We conclude that food hypersensitivities are present in SCWTs affected with the syndrome of PLE/PLN. Mild inflammatory bowel disease was already established in the 6 SCWTs of this report at the time of study, making it impossible to determine if food allergies were the cause or result of the enteric disease.
ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.2000.tb01501.x