Intravascular leukostasis and systemic aspergillosis in a horse with subleukemic acute myelomonocytic leukemia

Leukemia is a neoplastic disease of one or more of the cell types of the hemopoietic system and is rarely diagnosed in the horse. This report describes a case of subleukemic acute myelomonocytic leukemia in an 11 ‐year‐old gelding. Preliminary cytological diagnosis was supported by two types of labo...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 1994-07, Vol.8 (4), p.258-263
Main Authors: Buechner-Maxwell, V. (Veterinary Teaching Hospital, East Lansing, MI.), Zhang, C, Robertson, J, Jain, N.C, Antczak, D.F, Feldman, B.F, Murray, M.J
Format: Article
Language:English
Subjects:
Animals
Aspergillosis - complications
Aspergillosis - diagnosis
Aspergillosis - veterinary
ASPERGILLUS
BLOOD
BLOOD CHEMISTRY
BLOOD COMPOSITION
BLOOD PICTURE
CABALLOS
CASE STUDIES
CELL CULTURE
CHEVAL
COLON
COMPOSICION DE LA SANGRE
COMPOSITION DU SANG
CULTIVO DE CELULAS
CULTURE DE CELLULE
DIAGNOSIS
DIAGNOSTIC
DIAGNOSTICO
ESTUDIOS DE CASOS PRACTICOS
ETUDE DE CAS
FLOW CYTOMETRY
FOIE
Fungemia - complications
Fungemia - diagnosis
Fungemia - veterinary
HIGADO
HISTOPATHOLOGIE
HISTOPATHOLOGY
HISTOPATOLOGIA
Horse Diseases - diagnosis
HORSES
INTESTIN
INTESTINES
INTESTINOS
KIDNEYS
LEUCEMIA
LEUCEMIE
LEUCOCITOS
LEUCOCYTE
LEUKAEMIA
Leukemia, Myelomonocytic, Acute - complications
Leukemia, Myelomonocytic, Acute - diagnosis
Leukemia, Myelomonocytic, Acute - veterinary
LEUKOCYTES
Leukocytosis - complications
Leukocytosis - diagnosis
Leukocytosis - veterinary
LIVER
LUNGS
Male
MICOSIS
MYCOSE
MYCOSES
POUMON
PULMONES
REIN
RINONES
SANG
SANGRE
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Description
Summary:Leukemia is a neoplastic disease of one or more of the cell types of the hemopoietic system and is rarely diagnosed in the horse. This report describes a case of subleukemic acute myelomonocytic leukemia in an 11 ‐year‐old gelding. Preliminary cytological diagnosis was supported by two types of laboratory investigations. Cytochemical characterization of blood and bone marrow neoplastic cells was consistent with a myelomonocytic origin. Neoplastic blast cells in peripheral blood were labeled by monoclonal antibodies specific for cell surface molecules of horse granulocytes, but they were not labeled by antibodies to T‐ or B‐lymphocytes or macrophages. Treatment was attempted but was unsuccessful. At necropsy, intravascular leukostasis was present in all tissues examined. Fungal hyphae were also found in lung interstitium and colonic submucosa, suggesting the presence of a systemic mycosis. Nucleated cells were isolated from peripheral blood and cultured in vitro; they survived for up to 2 weeks and had evidence of cell division that was not sustained. Frozenthawed cells stored in liquid nitrogen were also successfully cultured in vitro, but no permanent cell lines could be established.
ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.1994.tb03229.x