Preparation and in vitro evaluation of new pH-sensitive hydrogel beads for oral delivery of protein drugs

New biodegradable pH-responsive hydrogel beads based on chemically modified chitosan and sodium alginate were prepared and characterized for the controlled release study of protein drugs in the small intestine. The ionotropic gelation reaction was carried out under mild aqueous conditions, which sho...

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Bibliographic Details
Published in:Journal of applied polymer science 2010-03, Vol.115 (5), p.2828-2837
Main Authors: El-Sherbiny, I.M, Abdel-Bary, E.M, Harding, D.R.K
Format: Article
Language:English
Subjects:
alginate
Applied sciences
Beads
Biological and medical sciences
Chitosan
Computer simulation
Controlled release
Drugs
Exact sciences and technology
General pharmacology
grafting
Hydrogels
In vitro testing
Medical sciences
Organic polymers
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Properties and characterization
protein drugs
Proteins
Solution and gel properties
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Description
Summary:New biodegradable pH-responsive hydrogel beads based on chemically modified chitosan and sodium alginate were prepared and characterized for the controlled release study of protein drugs in the small intestine. The ionotropic gelation reaction was carried out under mild aqueous conditions, which should be appropriate for the retention of the biological activity of an uploaded protein drug. The equilibrium swelling studies were carried out for the hydrogel beads at 37°C in simulated gastric (SGF) and simulated intestinal (SIF) fluids. Bovine serum albumin (BSA), a model for protein drugs was entrapped in the hydrogels and the in vitro drug release profiles were established at 37°C in SGF and SIF. The preliminary investigation of the hydrogel beads prepared in this study showed high entrapment efficiency (up to 97%) and promising release profiles of BSA.
ISSN:0021-8995
1097-4628
1097-4628
DOI:10.1002/app.30881