Sex differences in sleep after a single oral morning dose of olanzapine in healthy volunteers

Objective Polysomnography abnormalities are frequent in schizophrenia and have been correlated with clinical variables. Because women with schizophrenia present a general better clinical outcome than men, we aimed to determine whether sex differences in antipsychotic‐induced effects on sleep could c...

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Published in:Human psychopharmacology 2011-10, Vol.26 (7), p.498-507
Main Authors: Giménez, Sandra, Romero, Sergio, Gich, Ignasi, Clos, Susana, Grasa, Eva, Rosa-María, Antonijoan, Barbanoj, Manuel-José
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Antipsychotic Agents - blood
Antipsychotic Agents - pharmacology
Benzodiazepines - blood
Benzodiazepines - pharmacology
Brassica
Cross-Over Studies
Double-Blind Method
Drugs
EEG
Electroencephalography
Female
healthy volunteers
Humans
Hypnotics
Male
Mental disorders
Neuroleptics
olanzapine
Pharmacodynamics
Pharmacokinetics
Polysomnography
Population studies
Schizophrenia
Sex
Sex differences
Sex Factors
Sleep
Sleep - drug effects
spectral analysis
Young Adult
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Summary:Objective Polysomnography abnormalities are frequent in schizophrenia and have been correlated with clinical variables. Because women with schizophrenia present a general better clinical outcome than men, we aimed to determine whether sex differences in antipsychotic‐induced effects on sleep could contribute to this difference. Methods Single oral morning doses of olanzapine (5 mg) were administered to 10 men and 10 women. Sleep variables were evaluated using traditional polysomnography Rechstschaffen and Kales criteria and all‐night sleep electroencephalogram spectral analysis. Drug plasma concentrations were also measured. Results Significant sex‐by‐drug interactions were obtained in slow‐wave sleep. After olanzapine, women showed an increase in slow‐wave sleep, whereas men showed a decrease. We did not observe sex differences in olanzapine‐induced hypnotic effects. Neither did we find any significant differences in pharmacokinetic parameters between sexes. Significant sex effects were observed in deep sleep, with women showing longer periods than men. Conclusion Our results showed significant pharmacodynamic differences in olanzapine sleep effects between men and women. Further studies in clinical populations are needed to assess if these sex‐based differences suggest that optimal treatment and doses should differ between men and women. Copyright © 2011 John Wiley & Sons, Ltd.
ISSN:0885-6222
1099-1077
1099-1077
DOI:10.1002/hup.1232