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Predictive value of immunologic parameters and HIV RNA in relation to humoral pneumococcal polysaccharide vaccine responses in patients with HIV infection

In the study presented here immunologic markers and HIV RNA were related to specific antibody responses in 50 HIV-infected patients who had moderate immunodeficiency (median CD4+, 295) and were vaccinated with a pneumococcal polysaccharide vaccine. Low responses were associated with low IgG2 or high...

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Published in:	European journal of clinical microbiology & infectious diseases 2002-09, Vol.21 (9), p.688-690
Main Authors:	KVALE, D, AABERGE, I. S, FRØLAND, S. S
Format:	Article
Language:	English
Subjects:	Adult Antibody Formation - physiology Bacterial diseases Biological and medical sciences CD4 antigen CD4 Lymphocyte Count CD4-Positive T-Lymphocytes Cell number Female HIV Infections - diagnosis HIV Infections - immunology HIV-1 - immunology Human bacterial diseases Human immunodeficiency virus Human viral diseases Humans Immunodeficiency Immunoglobulin G Immunoglobulin M Infection Infectious diseases Logistic Models Male Medical sciences Middle Aged Pneumococcal Infections - immunology Pneumococcal Infections - prevention & control Pneumococcal Vaccines - administration & dosage Polysaccharides Predictive Value of Tests Probability Prognosis Prospective Studies Regression analysis RNA RNA, Viral - analysis Sensitivity and Specificity Staphylococcal infections, streptococcal infections, pneumococcal infections Streptococcus pneumoniae Vaccination Vaccines Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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description	In the study presented here immunologic markers and HIV RNA were related to specific antibody responses in 50 HIV-infected patients who had moderate immunodeficiency (median CD4+, 295) and were vaccinated with a pneumococcal polysaccharide vaccine. Low responses were associated with low IgG2 or high IgM levels ( P=0.01) and good responses with high IgG4 ( P=0.05) or IgG2 ( P=0.07) or low beta(2) microglobulin ( P=0.04) levels. A combination of IgG2 levels >1.0 g/l and IgM
doi_str_mv	10.1007/s10096-002-0803-4
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S</creatorcontrib><creatorcontrib>FRØLAND, S. S</creatorcontrib><title>Predictive value of immunologic parameters and HIV RNA in relation to humoral pneumococcal polysaccharide vaccine responses in patients with HIV infection</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>In the study presented here immunologic markers and HIV RNA were related to specific antibody responses in 50 HIV-infected patients who had moderate immunodeficiency (median CD4+, 295) and were vaccinated with a pneumococcal polysaccharide vaccine. Low responses were associated with low IgG2 or high IgM levels ( P=0.01) and good responses with high IgG4 ( P=0.05) or IgG2 ( P=0.07) or low beta(2) microglobulin ( P=0.04) levels. A combination of IgG2 levels >1.0 g/l and IgM <1.6 g/l at baseline significantly predicted a twofold or better response in logistic regression analysis ( P=0.025). 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subjects	Adult Antibody Formation - physiology Bacterial diseases Biological and medical sciences CD4 antigen CD4 Lymphocyte Count CD4-Positive T-Lymphocytes Cell number Female HIV Infections - diagnosis HIV Infections - immunology HIV-1 - immunology Human bacterial diseases Human immunodeficiency virus Human viral diseases Humans Immunodeficiency Immunoglobulin G Immunoglobulin M Infection Infectious diseases Logistic Models Male Medical sciences Middle Aged Pneumococcal Infections - immunology Pneumococcal Infections - prevention & control Pneumococcal Vaccines - administration & dosage Polysaccharides Predictive Value of Tests Probability Prognosis Prospective Studies Regression analysis RNA RNA, Viral - analysis Sensitivity and Specificity Staphylococcal infections, streptococcal infections, pneumococcal infections Streptococcus pneumoniae Vaccination Vaccines Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
title	Predictive value of immunologic parameters and HIV RNA in relation to humoral pneumococcal polysaccharide vaccine responses in patients with HIV infection
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