Predictive value of immunologic parameters and HIV RNA in relation to humoral pneumococcal polysaccharide vaccine responses in patients with HIV infection

In the study presented here immunologic markers and HIV RNA were related to specific antibody responses in 50 HIV-infected patients who had moderate immunodeficiency (median CD4+, 295) and were vaccinated with a pneumococcal polysaccharide vaccine. Low responses were associated with low IgG2 or high...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2002-09, Vol.21 (9), p.688-690
Main Authors: KVALE, D, AABERGE, I. S, FRØLAND, S. S
Format: Article
Language:English
Subjects:
Adult
Antibody Formation - physiology
Bacterial diseases
Biological and medical sciences
CD4 antigen
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes
Cell number
Female
HIV Infections - diagnosis
HIV Infections - immunology
HIV-1 - immunology
Human bacterial diseases
Human immunodeficiency virus
Human viral diseases
Humans
Immunodeficiency
Immunoglobulin G
Immunoglobulin M
Infection
Infectious diseases
Logistic Models
Male
Medical sciences
Middle Aged
Pneumococcal Infections - immunology
Pneumococcal Infections - prevention & control
Pneumococcal Vaccines - administration & dosage
Polysaccharides
Predictive Value of Tests
Probability
Prognosis
Prospective Studies
Regression analysis
RNA
RNA, Viral - analysis
Sensitivity and Specificity
Staphylococcal infections, streptococcal infections, pneumococcal infections
Streptococcus pneumoniae
Vaccination
Vaccines
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Description
Summary:In the study presented here immunologic markers and HIV RNA were related to specific antibody responses in 50 HIV-infected patients who had moderate immunodeficiency (median CD4+, 295) and were vaccinated with a pneumococcal polysaccharide vaccine. Low responses were associated with low IgG2 or high IgM levels ( P=0.01) and good responses with high IgG4 ( P=0.05) or IgG2 ( P=0.07) or low beta(2) microglobulin ( P=0.04) levels. A combination of IgG2 levels >1.0 g/l and IgM
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-002-0803-4