Association of MICA and MICB alleles with symptomatic dengue infection

Abstract Dengue viruses (DV) are one of the most important arthropod-borne viral diseases in the developing world. DV can cause syndromes that are either self-limiting or severe. Allelic variants of human leukocyte antigen (HLA) genes have been demonstrated to be associated with disease susceptibili...

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Bibliographic Details
Published in:Human immunology 2011-10, Vol.72 (10), p.904-907
Main Authors: García, Gissel, del Puerto, Florencia, Pérez, Ana B, Sierra, Beatriz, Aguirre, Eglys, Kikuchi, Mihoko, Sánchez, Lizet, Hirayama, Kenji, Guzmán, María G
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alleles
Allergy and Immunology
Asymptomatic Infections
Cuba
Cuba - epidemiology
Dengue virus
Dengue Virus - immunology
Female
Gene Frequency
Genetic Predisposition to Disease
Genetic susceptibility
Genotype
Histocompatibility Antigens Class I - genetics
Histocompatibility Antigens Class I - immunology
Humans
Killer Cells, Natural - immunology
Lymphocyte Activation - genetics
Lymphocyte Activation - immunology
Male
MICA
MICB
Middle Aged
Molecular Typing
Polymorphism, Genetic
Severe Dengue - epidemiology
Severe Dengue - genetics
Severe Dengue - immunology
Severe Dengue - virology
Severity of Illness Index
T-Lymphocytes - immunology
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Summary:Abstract Dengue viruses (DV) are one of the most important arthropod-borne viral diseases in the developing world. DV can cause syndromes that are either self-limiting or severe. Allelic variants of human leukocyte antigen (HLA) genes have been demonstrated to be associated with disease susceptibility. Here we report the association of nonclassical HLA class I MICA–MICB genes with disease outcome during DV infection. A sequencing-based typing method and genotyping of MICA and MICB in a well-characterized group of Cuban individuals with dengue hemorrhagic fever (DHF), dengue fever (DF), or asymptomatic dengue infection (ADI) was performed. Statistical analysis revealed a tendency for MICA*008 and MICB*008 to associate with susceptibility to illness when symptomatic versus asymptomatic cases (odds ratio [OR] = 2.1, p v = 0.03, and OR = 10.4, p = 0.0096, respectively) were compared. Surprisingly, a stronger association of both allelic forms was observed for the DF patients compared with the ADI group (MICA*008, OR = 5.2, p = 0.0001; and MICB*008, OR = 13.2, p = 0.0025) rather than the severe cases. Major histocompatibility class I-related gene-related natural killer cells and/or γδ and αβ T-cell activation might regulate the development of symptomatic DF and DHF.
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2011.06.010