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8q24.3 and 11q25 chromosomal loci association with low HDL-C in metabolic syndrome
Eur J Clin Invest 2011; 41 (10): 1105–1112 Background High‐density lipoprotein cholesterol (HDL‐C) levels are low in Iranians. Low HDL‐C is the most frequent phenotype in metabolic syndrome (MetS) among the Iranian population (32%). This has been claimed to be related to genetic factors. Materials...
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| Published in: | European journal of clinical investigation 2011-10, Vol.41 (10), p.1105-1112 |
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| container_title | European journal of clinical investigation |
| container_volume | 41 |
| creator | Daneshpour, Maryam Sadat Rebai, Ahmed Houshmand, Massoud Alfadhli, Suad Zeinali, Sirous Hedayati, Mehdi Zarkesh, Maryam Azizi, Fereidoun |
| description | Eur J Clin Invest 2011; 41 (10): 1105–1112
Background High‐density lipoprotein cholesterol (HDL‐C) levels are low in Iranians. Low HDL‐C is the most frequent phenotype in metabolic syndrome (MetS) among the Iranian population (32%). This has been claimed to be related to genetic factors.
Materials and methods To investigate possible genes linked to this disorder, 12 microsatellite markers were selected. They were used in 107 families with MetS and low HDL‐C to analyse relevant association and linkage signals.
Result Family‐based association tests under the biallelic mode gave many positive association signals. Higher association – after correction for multiple testing – was found to be linked with marker D8S1743 and D11S1304 (P |
| doi_str_mv | 10.1111/j.1365-2362.2011.02516.x |
| format | article |
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Background High‐density lipoprotein cholesterol (HDL‐C) levels are low in Iranians. Low HDL‐C is the most frequent phenotype in metabolic syndrome (MetS) among the Iranian population (32%). This has been claimed to be related to genetic factors.
Materials and methods To investigate possible genes linked to this disorder, 12 microsatellite markers were selected. They were used in 107 families with MetS and low HDL‐C to analyse relevant association and linkage signals.
Result Family‐based association tests under the biallelic mode gave many positive association signals. Higher association – after correction for multiple testing – was found to be linked with marker D8S1743 and D11S1304 (P < 0·003). The obtained results suggested evidence for association with regions on chromosome 8, 11 and to a lesser degree on chromosome 16. Nonparametric linkage analysis performed by Merlin software gave no significant correlation for any of the chromosomal regions. By considering only families with positive Nonparametric Logarithm of odds (LOD) scores, higher association can clearly be visible with D16S3096 and D11S934.
Conclusions These results suggest that 8q22–24; 11q23–25 and 16q23–24 regions are very likely to contain genes that control HDL‐C level in Iranian families with metabolic syndrome.</description><identifier>ISSN: 0014-2972</identifier><identifier>EISSN: 1365-2362</identifier><identifier>DOI: 10.1111/j.1365-2362.2011.02516.x</identifier><identifier>PMID: 21443751</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Cholesterol, HDL - genetics ; Chromosomes, Human, Pair 11 - genetics ; Chromosomes, Human, Pair 16 - genetics ; Chromosomes, Human, Pair 8 - genetics ; Family ; Female ; General aspects ; Genetic Linkage - genetics ; Genetic Predisposition to Disease - genetics ; high-density lipoprotein cholesterol ; Humans ; Iran ; linkage ; Male ; Medical sciences ; Metabolic diseases ; Metabolic Syndrome - genetics ; microsatellite ; Microsatellite Repeats - genetics ; Middle Aged ; Miscellaneous ; Other metabolic disorders ; Pedigree ; Phenotype ; Prospective Studies ; Young Adult</subject><ispartof>European journal of clinical investigation, 2011-10, Vol.41 (10), p.1105-1112</ispartof><rights>2011 Research Institute for Endocrine Sciences, Shahid Beheshti MC, Tehran, Iran. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation</rights><rights>2015 INIST-CNRS</rights><rights>2011 Research Institute for Endocrine Sciences, Shahid Beheshti MC, Tehran, Iran. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4706-35a1882c11147f4d113ac084e5387fc848b431ff42cbe8e2301d9a7bbf7d25e63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2362.2011.02516.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2362.2011.02516.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24492241$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21443751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Daneshpour, Maryam Sadat</creatorcontrib><creatorcontrib>Rebai, Ahmed</creatorcontrib><creatorcontrib>Houshmand, Massoud</creatorcontrib><creatorcontrib>Alfadhli, Suad</creatorcontrib><creatorcontrib>Zeinali, Sirous</creatorcontrib><creatorcontrib>Hedayati, Mehdi</creatorcontrib><creatorcontrib>Zarkesh, Maryam</creatorcontrib><creatorcontrib>Azizi, Fereidoun</creatorcontrib><title>8q24.3 and 11q25 chromosomal loci association with low HDL-C in metabolic syndrome</title><title>European journal of clinical investigation</title><addtitle>Eur J Clin Invest</addtitle><description>Eur J Clin Invest 2011; 41 (10): 1105–1112
Background High‐density lipoprotein cholesterol (HDL‐C) levels are low in Iranians. Low HDL‐C is the most frequent phenotype in metabolic syndrome (MetS) among the Iranian population (32%). This has been claimed to be related to genetic factors.
Materials and methods To investigate possible genes linked to this disorder, 12 microsatellite markers were selected. They were used in 107 families with MetS and low HDL‐C to analyse relevant association and linkage signals.
Result Family‐based association tests under the biallelic mode gave many positive association signals. Higher association – after correction for multiple testing – was found to be linked with marker D8S1743 and D11S1304 (P < 0·003). The obtained results suggested evidence for association with regions on chromosome 8, 11 and to a lesser degree on chromosome 16. Nonparametric linkage analysis performed by Merlin software gave no significant correlation for any of the chromosomal regions. By considering only families with positive Nonparametric Logarithm of odds (LOD) scores, higher association can clearly be visible with D16S3096 and D11S934.
Conclusions These results suggest that 8q22–24; 11q23–25 and 16q23–24 regions are very likely to contain genes that control HDL‐C level in Iranian families with metabolic syndrome.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cholesterol, HDL - genetics</subject><subject>Chromosomes, Human, Pair 11 - genetics</subject><subject>Chromosomes, Human, Pair 16 - genetics</subject><subject>Chromosomes, Human, Pair 8 - genetics</subject><subject>Family</subject><subject>Female</subject><subject>General aspects</subject><subject>Genetic Linkage - genetics</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>high-density lipoprotein cholesterol</subject><subject>Humans</subject><subject>Iran</subject><subject>linkage</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metabolic Syndrome - genetics</subject><subject>microsatellite</subject><subject>Microsatellite Repeats - genetics</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Other metabolic disorders</subject><subject>Pedigree</subject><subject>Phenotype</subject><subject>Prospective Studies</subject><subject>Young Adult</subject><issn>0014-2972</issn><issn>1365-2362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kU1PGzEQhi1UBCnwF5AvVXvZxeOPtffQQxUgICIqIRBHy-v1Cqf7QdYbJfn39ZI03OrLWJ7nnfHMixAGkkI8V4sUWCYSyjKaUgKQEiogSzdHaHJIfEETQoAnNJf0FH0NYUEIUcDoCTqlwDmTAiboSS0pTxk2bYkBllRg-9Z3TRe6xtS47qzHJoQYzOC7Fq_98BZf1_juep5MsW9x4wZTdLW3OGzbMkrdOTquTB3cxT6eoZfbm-fpXTL_Pbuf_ponlkuSJUwYUIraOA-XFS8BmLFEcSeYkpVVXBWcQVVxagunHGUEytzIoqhkSYXL2Bn6vqv73nfLlQuDbnywrq5N67pV0CpXismcQyR__JcEKRjPYkcR0cs9uioaV-r33jem3-p_G4vAtz1ggjV11ZvW-vDJcZ5T-tHz545b-9ptD3kgenRQL_RolB6N0qOD-sNBvdE30_vxFvXJTu_D4DYHven_6EzGn-jXx5m-fobb2YPg-pH9BWkXmbQ</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Daneshpour, Maryam Sadat</creator><creator>Rebai, Ahmed</creator><creator>Houshmand, Massoud</creator><creator>Alfadhli, Suad</creator><creator>Zeinali, Sirous</creator><creator>Hedayati, Mehdi</creator><creator>Zarkesh, Maryam</creator><creator>Azizi, Fereidoun</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201110</creationdate><title>8q24.3 and 11q25 chromosomal loci association with low HDL-C in metabolic syndrome</title><author>Daneshpour, Maryam Sadat ; Rebai, Ahmed ; Houshmand, Massoud ; Alfadhli, Suad ; Zeinali, Sirous ; Hedayati, Mehdi ; Zarkesh, Maryam ; Azizi, Fereidoun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4706-35a1882c11147f4d113ac084e5387fc848b431ff42cbe8e2301d9a7bbf7d25e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cholesterol, HDL - genetics</topic><topic>Chromosomes, Human, Pair 11 - genetics</topic><topic>Chromosomes, Human, Pair 16 - genetics</topic><topic>Chromosomes, Human, Pair 8 - genetics</topic><topic>Family</topic><topic>Female</topic><topic>General aspects</topic><topic>Genetic Linkage - genetics</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>high-density lipoprotein cholesterol</topic><topic>Humans</topic><topic>Iran</topic><topic>linkage</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metabolic Syndrome - genetics</topic><topic>microsatellite</topic><topic>Microsatellite Repeats - genetics</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Other metabolic disorders</topic><topic>Pedigree</topic><topic>Phenotype</topic><topic>Prospective Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Daneshpour, Maryam Sadat</creatorcontrib><creatorcontrib>Rebai, Ahmed</creatorcontrib><creatorcontrib>Houshmand, Massoud</creatorcontrib><creatorcontrib>Alfadhli, Suad</creatorcontrib><creatorcontrib>Zeinali, Sirous</creatorcontrib><creatorcontrib>Hedayati, Mehdi</creatorcontrib><creatorcontrib>Zarkesh, Maryam</creatorcontrib><creatorcontrib>Azizi, Fereidoun</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Daneshpour, Maryam Sadat</au><au>Rebai, Ahmed</au><au>Houshmand, Massoud</au><au>Alfadhli, Suad</au><au>Zeinali, Sirous</au><au>Hedayati, Mehdi</au><au>Zarkesh, Maryam</au><au>Azizi, Fereidoun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>8q24.3 and 11q25 chromosomal loci association with low HDL-C in metabolic syndrome</atitle><jtitle>European journal of clinical investigation</jtitle><addtitle>Eur J Clin Invest</addtitle><date>2011-10</date><risdate>2011</risdate><volume>41</volume><issue>10</issue><spage>1105</spage><epage>1112</epage><pages>1105-1112</pages><issn>0014-2972</issn><eissn>1365-2362</eissn><notes>istex:BF6FBD8B67777E10C46FD6C6DF427FB21793DC01</notes><notes>ark:/67375/WNG-DT1FGK54-N</notes><notes>ArticleID:ECI2516</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Eur J Clin Invest 2011; 41 (10): 1105–1112
Background High‐density lipoprotein cholesterol (HDL‐C) levels are low in Iranians. Low HDL‐C is the most frequent phenotype in metabolic syndrome (MetS) among the Iranian population (32%). This has been claimed to be related to genetic factors.
Materials and methods To investigate possible genes linked to this disorder, 12 microsatellite markers were selected. They were used in 107 families with MetS and low HDL‐C to analyse relevant association and linkage signals.
Result Family‐based association tests under the biallelic mode gave many positive association signals. Higher association – after correction for multiple testing – was found to be linked with marker D8S1743 and D11S1304 (P < 0·003). The obtained results suggested evidence for association with regions on chromosome 8, 11 and to a lesser degree on chromosome 16. Nonparametric linkage analysis performed by Merlin software gave no significant correlation for any of the chromosomal regions. By considering only families with positive Nonparametric Logarithm of odds (LOD) scores, higher association can clearly be visible with D16S3096 and D11S934.
Conclusions These results suggest that 8q22–24; 11q23–25 and 16q23–24 regions are very likely to contain genes that control HDL‐C level in Iranian families with metabolic syndrome.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21443751</pmid><doi>10.1111/j.1365-2362.2011.02516.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Biological and medical sciences Cholesterol, HDL - genetics Chromosomes, Human, Pair 11 - genetics Chromosomes, Human, Pair 16 - genetics Chromosomes, Human, Pair 8 - genetics Family Female General aspects Genetic Linkage - genetics Genetic Predisposition to Disease - genetics high-density lipoprotein cholesterol Humans Iran linkage Male Medical sciences Metabolic diseases Metabolic Syndrome - genetics microsatellite Microsatellite Repeats - genetics Middle Aged Miscellaneous Other metabolic disorders Pedigree Phenotype Prospective Studies Young Adult |
| title | 8q24.3 and 11q25 chromosomal loci association with low HDL-C in metabolic syndrome |
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