8q24.3 and 11q25 chromosomal loci association with low HDL-C in metabolic syndrome

Eur J Clin Invest 2011; 41 (10): 1105–1112 Background  High‐density lipoprotein cholesterol (HDL‐C) levels are low in Iranians. Low HDL‐C is the most frequent phenotype in metabolic syndrome (MetS) among the Iranian population (32%). This has been claimed to be related to genetic factors. Materials...

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Bibliographic Details
Published in:European journal of clinical investigation 2011-10, Vol.41 (10), p.1105-1112
Main Authors: Daneshpour, Maryam Sadat, Rebai, Ahmed, Houshmand, Massoud, Alfadhli, Suad, Zeinali, Sirous, Hedayati, Mehdi, Zarkesh, Maryam, Azizi, Fereidoun
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Cholesterol, HDL - genetics
Chromosomes, Human, Pair 11 - genetics
Chromosomes, Human, Pair 16 - genetics
Chromosomes, Human, Pair 8 - genetics
Family
Female
General aspects
Genetic Linkage - genetics
Genetic Predisposition to Disease - genetics
high-density lipoprotein cholesterol
Humans
Iran
linkage
Male
Medical sciences
Metabolic diseases
Metabolic Syndrome - genetics
microsatellite
Microsatellite Repeats - genetics
Middle Aged
Miscellaneous
Other metabolic disorders
Pedigree
Phenotype
Prospective Studies
Young Adult
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Summary:Eur J Clin Invest 2011; 41 (10): 1105–1112 Background  High‐density lipoprotein cholesterol (HDL‐C) levels are low in Iranians. Low HDL‐C is the most frequent phenotype in metabolic syndrome (MetS) among the Iranian population (32%). This has been claimed to be related to genetic factors. Materials and methods  To investigate possible genes linked to this disorder, 12 microsatellite markers were selected. They were used in 107 families with MetS and low HDL‐C to analyse relevant association and linkage signals. Result  Family‐based association tests under the biallelic mode gave many positive association signals. Higher association – after correction for multiple testing – was found to be linked with marker D8S1743 and D11S1304 (P 
ISSN:0014-2972
1365-2362
DOI:10.1111/j.1365-2362.2011.02516.x