Serum visfatin and vaspin levels in prepubertal children: effect of obesity and weight loss after behavior modifications on their secretion and relationship with glucose metabolism

To investigate the impact of obesity, weight loss and oral glucose ingestion on serum visfatin and vaspin levels in prepubertal children. A total of 100 prepubertal obese Caucasian children (OB) and 42 controls (C) were studied. The OB group was studied at baseline and after moderate (n=46) and exte...

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Bibliographic Details
Published in:International Journal of Obesity 2011-10, Vol.35 (10), p.1355-1362
Main Authors: MARTOS-MORENO, G. A, KRATZSCH, J, KÖRNER, A, BARRIOS, V, HAWKINS, F, KIESS, W, ARGENTE, J
Format: Article
Language:English
Subjects:
Area Under Curve
Biological and medical sciences
Body fat
Body Mass Index
Child
Child, Preschool
Cytokines - blood
Fat cells
Female
General aspects
Glucose - metabolism
Glucose Tolerance Test
Humans
Insulin Resistance
Male
Medical sciences
Metabolic diseases
Nicotinamide Phosphoribosyltransferase - blood
Obesity
Obesity - metabolism
Obesity - psychology
Obesity - therapy
Obesity in children
Physiological aspects
Puberty
Serpins - blood
Weight Loss
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Summary:To investigate the impact of obesity, weight loss and oral glucose ingestion on serum visfatin and vaspin levels in prepubertal children. A total of 100 prepubertal obese Caucasian children (OB) and 42 controls (C) were studied. The OB group was studied at baseline and after moderate (n=46) and extensive (n=14) body mass index (BMI) reduction by conservative treatment, undergoing body composition studies (dual-energy X-ray absorptiometry) and oral glucose tolerance tests (OGTTs). Serum visfatin and vaspin levels were studied throughout the OGTT, as were their relationships with insulin, leptin, leptin soluble receptor (sOB-R), adiponectin (total and high molecular weight), resistin, interleukin-6 (IL-6) and tumor necrosis factor-α levels at every time point. OB had higher visfatin (P
ISSN:0307-0565
1476-5497
DOI:10.1038/ijo.2010.280