Increasing incidence of Barrett's oesophagus: a population-based study

Oesophageal adenocarcinoma, a highly fatal cancer, has risen in incidence in Western societies, but it is unclear whether this is due to increasing incidence of its precursor condition, Barrett's oesophagus (BO) or whether the proportion of BO patients undergoing malignant progression has incre...

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Bibliographic Details
Published in:	European journal of epidemiology 2011-09, Vol.26 (9), p.739-745
Main Authors:	Coleman, Helen G., Bhat, Shivaram, Murray, Liam J., McManus, Damian, Gavin, Anna T., Johnston, Brian T.
Format:	Article
Language:	eng
Subjects:	Adenocarcinoma Adolescent Adult Age Distribution Age groups Aged Aged, 80 and over Barrett esophagus Barrett Esophagus - diagnosis Barrett Esophagus - epidemiology Biological and medical sciences Biopsies Biopsy - statistics & numerical data Biopsy - trends Bleeding time Cardiology Educational buildings Endoscopy Epidemiology Esophagoscopy - statistics & numerical data Esophagoscopy - trends Esophagus Female GASTRO-INTESTINAL EPIDEMIOLOGY Gastroenterology. Liver. Pancreas. Abdomen General aspects Humans Incidence Infectious Diseases Male Medical disorders Medical sciences Medicine Medicine & Public Health Middle Aged Miscellaneous Northern Ireland - epidemiology Oncology Other diseases. Semiology Population dynamics Population Surveillance Public Health Public health. Hygiene Public health. Hygiene-occupational medicine Sex Distribution Sex Factors Young Adult
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Summary:	Oesophageal adenocarcinoma, a highly fatal cancer, has risen in incidence in Western societies, but it is unclear whether this is due to increasing incidence of its precursor condition, Barrett's oesophagus (BO) or whether the proportion of BO patients undergoing malignant progression has increased in the face of unchanged BO incidence. Data from population-based studies of BO incidence is limited, with equivocal results to date difficult to distinguish from changes in endoscopie practices. The aim of this study was to assess population trends in Barrett's oesophagus (BO) diagnoses in relation to endoscopy and biopsy rates over a 13 year period. The Northern Ireland Barrett's oesophagus Register (NIBR) is a population-based register of all 9,329 adults diagnosed with columnar epithelium of the oesophagus in Northern Ireland between 1993 and 2005, of whom 58.3% were male. European age-standardised annual BO incidence rates were calculated per 100,000 of the population, per 100 endoscopies and per 100 endoscopies including an oesophageal biopsy. Average annual BO incidence rates rose by 159% during the study period, increasing from 23.9/100,000 during 1993—1997 to 62.0/100,000 during 2002—2005. This elevation far exceeded corresponding increases in rates of endoscopies and oesophageal biopsies being conducted. BO incidence increased most markedly in individuals aged
ISSN:	0393-2990 1573-7284