Association between serum ferritin concentrations and depressive symptoms in Japanese municipal employees

Abstract It remains unclear whether levels of body iron store are related to milder forms of depression, which are more common among apparently healthy people. We examined the association between serum ferritin concentrations and depressive symptoms among 312 men and 216 women working in two municip...

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Bibliographic Details
Published in:Psychiatry research 2011-10, Vol.189 (3), p.368-372
Main Authors: Yi, Siyan, Nanri, Akiko, Poudel-Tandukar, Kalpana, Nonaka, Daisuke, Matsushita, Yumi, Hori, Ai, Mizoue, Tetsuya
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Age Factors
Asian Continental Ancestry Group
Biological and medical sciences
Body iron store
Depression
Depression - blood
Depression - epidemiology
Depressive symptoms
Employment
Female
Ferritins - blood
General population
Humans
Japanese
Logistic Models
Male
Medical sciences
Middle Aged
MMPI
Mood disorders
Psychiatric Status Rating Scales
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Serum ferritin
Sex Factors
Statistics, Nonparametric
Surveys and Questionnaires
Urban Population
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Summary:Abstract It remains unclear whether levels of body iron store are related to milder forms of depression, which are more common among apparently healthy people. We examined the association between serum ferritin concentrations and depressive symptoms among 312 men and 216 women working in two municipal offices in Japan. Depressive symptoms were assessed by using the Center for Epidemiologic Studies Depression (CES-D) scale. In men, increased prevalence of depressive symptoms (defined by using a cutoff value of ≥ 19) was significantly associated with decreased levels of serum ferritin. In age- and study-site-adjusted models, ORs (95% CIs) for depressive symptoms for men in first, second, third, and fourth quartiles of serum ferritin concentrations were 2.83 (1.01–7.94), 1.74 (0.87–3.49), 1.33 (0.71–2.47), and 1.00 (reference), respectively ( p for trend = 0.02). In multivariate-adjusted model, ORs (95% CIs) in first, second, third, and fourth quartiles of serum ferritin concentrations were 2.88 (0.93–8.91), 1.91 (0.90–4.05), 1.28 (0.66–2.49), and 1.00 (reference), respectively ( p for trend = 0.03). No significant association was detected in women. Our finding that men with lower levels of serum ferritin concentrations had a higher prevalence of depressive symptoms suggests that adverse psychological effects may be implicated in iron deficiency among middle-age Japanese workers.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2011.03.009