Morphologic and nanomechanical characterization of bone tissue growth around bioactive sol–gel coatings containing wollastonite particles applied on stainless steel implants

Metals are widely used in orthopaedic and dental implants due to their excellent mechanical properties, but they do not bond naturally with mineralised bone and can release metallic particles that may result in the removal of the implant. These drawbacks may be overcome by protecting the metallic im...

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Bibliographic Details
Published in:Materials Science and Engineering C: Biomimetic and Supramolecular Systems 2011-04, Vol.31 (3), p.545-552
Main Authors: Ballarre, J: Seltzer R, Mendoza, E, Orellano, J C, Mai, Y-W, Garcia, C, Cere, S M
Format: Article
Language:English
Subjects:
Bones
Coatings
Materials science
Metal particles
Nanostructure
Stainless steels
Surgical implants
Wollastonite
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Summary:Metals are widely used in orthopaedic and dental implants due to their excellent mechanical properties, but they do not bond naturally with mineralised bone and can release metallic particles that may result in the removal of the implant. These drawbacks may be overcome by protecting the metallic implant with a biocompatible coating or adding bioactive particles to enhance implant fixation to the existing bone. Surgical grade stainless steel implants coated with tetraethoxysilane (TEOS)-methyltriethoxysilane (MTES) and 10 wt% of commercial wollastonite particles were implanted in the femur of Hokkaido rats. Transversal sections of the tibia samples were examined with SEM, AFM, histological analysis and nanoindentation experiments in air and under physiological conditions to characterise the hydroxyapatite deposits and the composition of the newly formed tissue around the implant. The results showed no presence of harmful ions or metallic particles in the surrounding tissues and the coating promoted formation and growth of new bone in the periphery of the implant, both in contact with the old bone (remodellation zone) and the marrow (new bone). The relative mechanical behaviour of old, remodelled and new bone tissues obtained in air cannot be directly extrapolated to live or in vivo-physiological response. This may be caused by the different degree of hydration and SBF/structure interaction among the three bone types but these values are near the normal hydrated bone response.
ISSN:0928-4931
DOI:10.1016/j.msec.2010.11.030