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Mutually reinforced multicomponent polysaccharide networks
Networks made from chitosan and alginate have been utilized as prospective tissue engineering scaffolds due to material biocompatibility and degradability. Calcium (Ca2+) is often added to these networks as a modifier for mechanical strength enhancement. In this work, we examined changes in the bulk...
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| Published in: | Biopolymers 2011-12, Vol.95 (12), p.840-851 |
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| container_title | Biopolymers |
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| creator | Hyland, Laura L. Taraban, Marc B. Hammouda, Boualem Bruce Yu, Y. |
| description | Networks made from chitosan and alginate have been utilized as prospective tissue engineering scaffolds due to material biocompatibility and degradability. Calcium (Ca2+) is often added to these networks as a modifier for mechanical strength enhancement. In this work, we examined changes in the bulk material properties of different concentrations of chitosan/alginate mixtures (2, 3, or 5% w/w) upon adding another modifier, chondroitin. We further examined how material properties depend on the order the modifiers, Ca2+ and chondroitin, were added. It was found that the addition of chondroitin significantly increased the mechanical strength of chitosan/alginate networks. Highest elastic moduli were obtained from samples made with mass fractions of 5% chitosan and alginate, modified by chondroitin first and then Ca2+. The elastic moduli in dry and hydrated states were (4.41 ± 0.52) MPa and (0.11 ± 0.01) MPa, respectively. Network porosity and density were slightly dependent on total polysaccharide concentration. Average pore size was slightly larger in samples modified by Ca2+ first and then chondroitin and in samples made with 3% starting mass fractions. Here, small‐angle neutron scattering (SANS) was utilized to examine mesh size of the fibrous networks, mass‐fractal parameters and average dimensions of the fiber cross‐sections prior to freeze‐drying. These studies revealed that addition of Ca2+ and chondroitin modifiers increased fiber compactness and thickness, respectively. Together these findings are consistent with improved network mechanical properties of the freeze‐dried materials. © 2011 Wiley Periodicals, Inc. Biopolymers 95: 840–851, 2011. |
| doi_str_mv | 10.1002/bip.21687 |
| format | article |
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Calcium (Ca2+) is often added to these networks as a modifier for mechanical strength enhancement. In this work, we examined changes in the bulk material properties of different concentrations of chitosan/alginate mixtures (2, 3, or 5% w/w) upon adding another modifier, chondroitin. We further examined how material properties depend on the order the modifiers, Ca2+ and chondroitin, were added. It was found that the addition of chondroitin significantly increased the mechanical strength of chitosan/alginate networks. Highest elastic moduli were obtained from samples made with mass fractions of 5% chitosan and alginate, modified by chondroitin first and then Ca2+. The elastic moduli in dry and hydrated states were (4.41 ± 0.52) MPa and (0.11 ± 0.01) MPa, respectively. Network porosity and density were slightly dependent on total polysaccharide concentration. Average pore size was slightly larger in samples modified by Ca2+ first and then chondroitin and in samples made with 3% starting mass fractions. Here, small‐angle neutron scattering (SANS) was utilized to examine mesh size of the fibrous networks, mass‐fractal parameters and average dimensions of the fiber cross‐sections prior to freeze‐drying. These studies revealed that addition of Ca2+ and chondroitin modifiers increased fiber compactness and thickness, respectively. Together these findings are consistent with improved network mechanical properties of the freeze‐dried materials. © 2011 Wiley Periodicals, Inc. Biopolymers 95: 840–851, 2011.</description><identifier>ISSN: 0006-3525</identifier><identifier>ISSN: 1097-0282</identifier><identifier>EISSN: 1097-0282</identifier><identifier>DOI: 10.1002/bip.21687</identifier><identifier>PMID: 21698596</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>alginate ; Alginates ; Alginates - chemistry ; Biocompatible Materials ; Biopolymers ; Calcium - chemistry ; Chitosan ; Chitosan - chemistry ; chondroitin ; Chondroitin - chemistry ; compression-tensile tester ; Compressive Strength ; correlation length ; Elasticity ; Fibers ; fractal dimensions ; freeze-dry ; Glucuronic Acid - chemistry ; Hexuronic Acids - chemistry ; Microscopy, Electron, Scanning - methods ; Models, Statistical ; Networks ; Polysaccharides ; Polysaccharides - chemistry ; Porosity ; Pressure ; scanning electron microscopy (SEM) ; Scattering, Small Angle ; small-angle neutron scattering (SANS) ; Strength ; Stress, Mechanical ; Tissue Engineering - methods ; Tissue Scaffolds - chemistry</subject><ispartof>Biopolymers, 2011-12, Vol.95 (12), p.840-851</ispartof><rights>Copyright © 2011 Wiley Periodicals, Inc.</rights><rights>2011 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4637-ba4be452d582e4bad70ecef66548fb9ac37b6bcec60bdd1873609437b74c75433</citedby><cites>FETCH-LOGICAL-c4637-ba4be452d582e4bad70ecef66548fb9ac37b6bcec60bdd1873609437b74c75433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbip.21687$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbip.21687$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21698596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hyland, Laura L.</creatorcontrib><creatorcontrib>Taraban, Marc B.</creatorcontrib><creatorcontrib>Hammouda, Boualem</creatorcontrib><creatorcontrib>Bruce Yu, Y.</creatorcontrib><title>Mutually reinforced multicomponent polysaccharide networks</title><title>Biopolymers</title><addtitle>Biopolymers</addtitle><description>Networks made from chitosan and alginate have been utilized as prospective tissue engineering scaffolds due to material biocompatibility and degradability. Calcium (Ca2+) is often added to these networks as a modifier for mechanical strength enhancement. In this work, we examined changes in the bulk material properties of different concentrations of chitosan/alginate mixtures (2, 3, or 5% w/w) upon adding another modifier, chondroitin. We further examined how material properties depend on the order the modifiers, Ca2+ and chondroitin, were added. It was found that the addition of chondroitin significantly increased the mechanical strength of chitosan/alginate networks. Highest elastic moduli were obtained from samples made with mass fractions of 5% chitosan and alginate, modified by chondroitin first and then Ca2+. The elastic moduli in dry and hydrated states were (4.41 ± 0.52) MPa and (0.11 ± 0.01) MPa, respectively. Network porosity and density were slightly dependent on total polysaccharide concentration. Average pore size was slightly larger in samples modified by Ca2+ first and then chondroitin and in samples made with 3% starting mass fractions. Here, small‐angle neutron scattering (SANS) was utilized to examine mesh size of the fibrous networks, mass‐fractal parameters and average dimensions of the fiber cross‐sections prior to freeze‐drying. These studies revealed that addition of Ca2+ and chondroitin modifiers increased fiber compactness and thickness, respectively. Together these findings are consistent with improved network mechanical properties of the freeze‐dried materials. © 2011 Wiley Periodicals, Inc. Biopolymers 95: 840–851, 2011.</description><subject>alginate</subject><subject>Alginates</subject><subject>Alginates - chemistry</subject><subject>Biocompatible Materials</subject><subject>Biopolymers</subject><subject>Calcium - chemistry</subject><subject>Chitosan</subject><subject>Chitosan - chemistry</subject><subject>chondroitin</subject><subject>Chondroitin - chemistry</subject><subject>compression-tensile tester</subject><subject>Compressive Strength</subject><subject>correlation length</subject><subject>Elasticity</subject><subject>Fibers</subject><subject>fractal dimensions</subject><subject>freeze-dry</subject><subject>Glucuronic Acid - chemistry</subject><subject>Hexuronic Acids - chemistry</subject><subject>Microscopy, Electron, Scanning - methods</subject><subject>Models, Statistical</subject><subject>Networks</subject><subject>Polysaccharides</subject><subject>Polysaccharides - chemistry</subject><subject>Porosity</subject><subject>Pressure</subject><subject>scanning electron microscopy (SEM)</subject><subject>Scattering, Small Angle</subject><subject>small-angle neutron scattering (SANS)</subject><subject>Strength</subject><subject>Stress, Mechanical</subject><subject>Tissue Engineering - methods</subject><subject>Tissue Scaffolds - chemistry</subject><issn>0006-3525</issn><issn>1097-0282</issn><issn>1097-0282</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqF0DlP7DAUBWALgWAeUPAH0HTwisB17HihAx6r2AoQpWU7NyKQDTsRb_49gQE6oLrS1XdOcQjZoLBDAdJdV3Y7KRVKLpAJBS0TSFW6SCYAIBKWpdkK-RPjIwDnjMIyWRmxVpkWE7J3OfSDrarZNGDZFG3wmE_roepL39Zd22DTT7u2mkXr_YMNZY7TBvuXNjzFNbJU2Cri-sddJXfHR7eHp8nF9cnZ4f5F4rlgMnGWO-RZmmcqRe5sLgE9FkJkXBVOW8-kE86jF-DynCrJBGg-PiX3MuOMrZKteW8X2ucBY2_qMnqsKttgO0SjNFdUafEmt3-UVDKgQCXQ3-nItJCg1Uj_zqkPbYwBC9OFsrZhNiLztr8Z9zfv-49286N2cDXmX_Jz8BHszsFLWeHs-yZzcHbzWZnME2Xs8f9XwoYnIySTmbm_OjHnB1JSefvPXLJXmEud4A</recordid><startdate>201112</startdate><enddate>201112</enddate><creator>Hyland, Laura L.</creator><creator>Taraban, Marc B.</creator><creator>Hammouda, Boualem</creator><creator>Bruce Yu, Y.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7U5</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>201112</creationdate><title>Mutually reinforced multicomponent polysaccharide networks</title><author>Hyland, Laura L. ; Taraban, Marc B. ; Hammouda, Boualem ; Bruce Yu, Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4637-ba4be452d582e4bad70ecef66548fb9ac37b6bcec60bdd1873609437b74c75433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>alginate</topic><topic>Alginates</topic><topic>Alginates - chemistry</topic><topic>Biocompatible Materials</topic><topic>Biopolymers</topic><topic>Calcium - chemistry</topic><topic>Chitosan</topic><topic>Chitosan - chemistry</topic><topic>chondroitin</topic><topic>Chondroitin - chemistry</topic><topic>compression-tensile tester</topic><topic>Compressive Strength</topic><topic>correlation length</topic><topic>Elasticity</topic><topic>Fibers</topic><topic>fractal dimensions</topic><topic>freeze-dry</topic><topic>Glucuronic Acid - chemistry</topic><topic>Hexuronic Acids - chemistry</topic><topic>Microscopy, Electron, Scanning - methods</topic><topic>Models, Statistical</topic><topic>Networks</topic><topic>Polysaccharides</topic><topic>Polysaccharides - chemistry</topic><topic>Porosity</topic><topic>Pressure</topic><topic>scanning electron microscopy (SEM)</topic><topic>Scattering, Small Angle</topic><topic>small-angle neutron scattering (SANS)</topic><topic>Strength</topic><topic>Stress, Mechanical</topic><topic>Tissue Engineering - methods</topic><topic>Tissue Scaffolds - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hyland, Laura L.</creatorcontrib><creatorcontrib>Taraban, Marc B.</creatorcontrib><creatorcontrib>Hammouda, Boualem</creatorcontrib><creatorcontrib>Bruce Yu, Y.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Biopolymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hyland, Laura L.</au><au>Taraban, Marc B.</au><au>Hammouda, Boualem</au><au>Bruce Yu, Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mutually reinforced multicomponent polysaccharide networks</atitle><jtitle>Biopolymers</jtitle><addtitle>Biopolymers</addtitle><date>2011-12</date><risdate>2011</risdate><volume>95</volume><issue>12</issue><spage>840</spage><epage>851</epage><pages>840-851</pages><issn>0006-3525</issn><issn>1097-0282</issn><eissn>1097-0282</eissn><notes>ark:/67375/WNG-JB7717TD-M</notes><notes>istex:34D4B762E85D672379556CA7363019D72F975ECA</notes><notes>ArticleID:BIP21687</notes><notes>Maryland Technology Development Corporation (TEDCO)</notes><notes>NIH - No. EB004416</notes><notes>This article was originally published online as an accepted preprint. The "Published Online" date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com</notes><notes>National Science Foundation - No. DMR-0944772</notes><notes>This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Networks made from chitosan and alginate have been utilized as prospective tissue engineering scaffolds due to material biocompatibility and degradability. Calcium (Ca2+) is often added to these networks as a modifier for mechanical strength enhancement. In this work, we examined changes in the bulk material properties of different concentrations of chitosan/alginate mixtures (2, 3, or 5% w/w) upon adding another modifier, chondroitin. We further examined how material properties depend on the order the modifiers, Ca2+ and chondroitin, were added. It was found that the addition of chondroitin significantly increased the mechanical strength of chitosan/alginate networks. Highest elastic moduli were obtained from samples made with mass fractions of 5% chitosan and alginate, modified by chondroitin first and then Ca2+. The elastic moduli in dry and hydrated states were (4.41 ± 0.52) MPa and (0.11 ± 0.01) MPa, respectively. Network porosity and density were slightly dependent on total polysaccharide concentration. Average pore size was slightly larger in samples modified by Ca2+ first and then chondroitin and in samples made with 3% starting mass fractions. Here, small‐angle neutron scattering (SANS) was utilized to examine mesh size of the fibrous networks, mass‐fractal parameters and average dimensions of the fiber cross‐sections prior to freeze‐drying. These studies revealed that addition of Ca2+ and chondroitin modifiers increased fiber compactness and thickness, respectively. Together these findings are consistent with improved network mechanical properties of the freeze‐dried materials. © 2011 Wiley Periodicals, Inc. Biopolymers 95: 840–851, 2011.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21698596</pmid><doi>10.1002/bip.21687</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | alginate Alginates Alginates - chemistry Biocompatible Materials Biopolymers Calcium - chemistry Chitosan Chitosan - chemistry chondroitin Chondroitin - chemistry compression-tensile tester Compressive Strength correlation length Elasticity Fibers fractal dimensions freeze-dry Glucuronic Acid - chemistry Hexuronic Acids - chemistry Microscopy, Electron, Scanning - methods Models, Statistical Networks Polysaccharides Polysaccharides - chemistry Porosity Pressure scanning electron microscopy (SEM) Scattering, Small Angle small-angle neutron scattering (SANS) Strength Stress, Mechanical Tissue Engineering - methods Tissue Scaffolds - chemistry |
| title | Mutually reinforced multicomponent polysaccharide networks |
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